- Her grandmother told her to become a funeral director, because she thought acting was very unpredictable, and funeral director would be a practical profession. As a result, she became an actress who played member of family who have funeral business on "Six Feet Under".
- Classically trained opera singer
- When she was a kid, she sang at weddings and funerals.
- Did her own singing in Psycho Beach Party (2000).
- Was author Audrey Niffenegger's personal choice for the role of Clare Anne Abshire in the adaptation of her novel The Time Traveler's Wife (2009). However, Niffberger was not involved with the production and Rachel McAdams was cast instead.
- Moved to New York because she wanted more theater in her life. She quickly got a part in the successful play "Exit the King" opposite Susan Sarandon and Geoffrey Rush.
- The last face seen on "Six Feet Under" is hers.
- Attended Choate Rosemary Hall in Wallingford, Connecticut, and Wilbur Cross High School in New Haven, Connecticut, but transferred and graduated from the High School in the Community, a magnet school also in New Haven. She also attended the Educational Center for the Arts, New Haven's performing arts school, and spent summers studying voice at Tanglewood in Massachusetts.
- She replaced Michelle Williams in Where the Wild Things Are (2009), after it was decided that Williams didn't quite match the filmmakers' vision of how the character should sound.
- Has 2 children with her husband Samuel H. Handel - a son named Orson Halcyon Handel (b. January 16, 2007) and a daughter (b. 2012).
- Was chosen as one of People Magazine's annual 100 Most Beautiful People in the World, Beauty at Every Age section, for age 29, in May 2007.
- Alan Ball and she once discussed the possibility of a guest role on True Blood (2008). According to Ambrose it never happened as "the timing didn't work out".
- National Theatre, London, making her UK stage debut in a major revival of "Buried Child" by Sam Shepard. (September 2004)
- Was a big fan of Parker Posey before she worked with her on The Return of Jezebel James (2008). After working on the show, they befriended.
- Her father, Frank, is a caterer, and her mother, Annie, is an interior designer.
- Lives in Manhattan (New York City) with her husband, Sam.
- Her father is of Italian descent while her mother is of German, English, and Irish ancestry.
- Stars in the Broadway revival of "Awake and Sing!" at the Belasco Theater. Previews begin March 23, 2006, toward an opening night of April 17. (April 2006)
- Appearing nightly in the Shakespeare in the Park production of "Romeo and Juliet," June 5-July 8, in New York City. Location: the Delacorte Theater (an open-air amphitheater), situated on the SW corner of the Great Lawn in Central Park, closest to the entrance at 81st St. and Central Park West. (June 2007)
- Husband Sam, a photographer, is originally from Boston.
- Has a younger brother, John.
- Lauren is taking piano lessons.
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