- He was the voice (uncredited) of Timothy Q. Mouse in Dumbo (1941).
- Brophy and his wife Annie became godparents to Robert Talmadge Keaton, the second son of Buster Keaton and Natalie Talmadge, in February 1924.
- The sidekick character that Ron Carey plays in Mel Brooks' 1976 Hitchcock parody "High Anxiety" is named Brophy in tribute to Edward Brophy who played dozens of sidekick parts throughout his career.
- Bald, raspy-voiced, cigar chewing, diminutive Hollywood character actor who specialized in playing gangsters, both in a comic or serious variety, at his peak during the 1930s and 1940s.
- Married Norma Talmadge's secretary, Annie, to whom he remained wed until his death in 1960. Annie died in 1963.
- Studied at the University of Virginia to become a lawyer, but harboring a desire to act he started "hanging around" Norma Talmadge's film studio in New York from 1918 in the hope of picking up work as an extra.
- Was a frequent contributor to the popular "True Detective Mysteries" series on the Mutual Radio network.
- Doiby Dickles, sidekick to DC Comic's Golden Age Green Lantern (Alan Scott), was modeled after Edward Brophy.
- Provided the (uncredited) voice of Harry the Horse on radio's Damon Runyon Theater, which ran throughout 1949.
- Was in three Oscar Best Picture nominees: The Champ (1931), The Thin Man (1934) and Naughty Marietta (1935).
- According to a Kansas City Times newspaper article of 31 May 1960 Edward Brophy's brother Thomas said he died while watching a prize fight on television.
- Entered films in 1919.
- Buried at Santa Monica's Woodlawn Cemetery.
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