Michael Keaton, Dwayne Adway, Katie Holmes, and Margaret Colin in First Daughter (2004)

Jeff Goldblum, Bill Pullman, Judd Hirsch, and Margaret Colin in Independence Day (1996)

Jeff Goldblum, Judd Hirsch, and Margaret Colin in Independence Day (1996)

Jeff Goldblum, Bill Pullman, Judd Hirsch, Robert Loggia, Margaret Colin, and James Rebhorn in Independence Day (1996)

Wallace Shawn and Margaret Colin in Gossip Girl (2007)

Heather Matarazzo, Margaret Colin, Gerrit Graham, and Dennis Haysbert in Now and Again (1999)

Eric Close and Margaret Colin in Now and Again (1999)

Heather Matarazzo and Margaret Colin in Now and Again (1999)

Wallace Shawn, Desmond Harrington, Kelly Rutherford, Michelle Trachtenberg, Penn Badgley, Margaret Colin, Blake Lively, Leighton Meester, Chace Crawford, Ed Westwick, and Zuzanna Szadkowski in Gossip Girl (2007)

Wallace Shawn, Desmond Harrington, Margaret Colin, Leighton Meester, and Ed Westwick in Gossip Girl (2007)

Wallace Shawn, Michelle Trachtenberg, Margaret Colin, Blake Lively, Leighton Meester, Chace Crawford, Ed Westwick, and Zuzanna Szadkowski in Gossip Girl (2007)

Wallace Shawn, Desmond Harrington, Kelly Rutherford, Michelle Trachtenberg, Penn Badgley, Margaret Colin, Blake Lively, Leighton Meester, Chace Crawford, Ed Westwick, Zuzanna Szadkowski, and Jeffrey Mowery in Gossip Girl (2007)

Margaret Colin and Leighton Meester in Gossip Girl (2007)

Margaret Colin, Blake Lively, Leighton Meester, and Zuzanna Szadkowski in Gossip Girl (2007)

Margaret Colin, Leighton Meester, and Ed Westwick in Gossip Girl (2007)

Joanne Whalley and Margaret Colin in Gossip Girl (2007)

Margaret Colin and Jay O. Sanders in The Familiar Stranger (2001)

Margaret Colin as Lana, Michael Shannon as John Rosow.

Margaret Colin at an event for The Social Network (2010)