- His father was in the clothing business, but eventually went bankrupt and moved the family to Chicago.
- Appeared in a scene with director Paul Mazursky in Down and Out in Beverly Hills, but Mazursky didn't like his own acting in the scene and cut it out. DeSantis is, however, still visible in the party scenes.
- Moved to L.A. in 1977.
- Owned very successful T-shirt business, Passing4sane and a soap company, Bubbletown, both deal with show business licensing. Picked as one of the 50 most influential people in licensing, by Licensing Magazine.
- Initially got involved in T-shirt design and sales to get him by while he pursued acting.
- Born in Long Island, NY, one of six children.
- Raised in Chicago, he attended New York University film school.
- Briefly attended Illinois Weselyan University to study acting.
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