- Best friend and Scrubs co-star Zach Braff is the godfather of his two youngest children.
- His Scrubs (2001) co-stars refer to him as "that guy from Clueless (1995)." Similarly, cast-mate Sarah Chalke is called "Becky Number Two," in reference to her role on Roseanne (1988).
- Is best friends with Scrubs (2001) co-star Zach Braff
- He has six children: a son named Sean Faison-Ince (b. 1996) with ex-girlfriend Audrey Ince; twins (a daughter named Kaya and a son named Dade, b. 1999) and a son named Kobe (b. 2001) with ex-wife Lisa Askey; and a son named Rocco (b. August 2013) and a daughter named Wilder Frances (b. April 2015) with wife Cacee Cobb.
- Is a big Star Wars fan.
- Graduated from the Professional Children's School in New York City with Jerry O'Connell, Sarah Michelle Gellar, and Cari Shayne.
- No relation to Frankie Faison of "Maximum Overdrive" and "True Colors" fame, despite a popular misconception.
- Ex-wife Lisa Askey died of undisclosed causes on March 2, 2017.
- Has worked as a lifeguard.
- His surname is pronounced "fay-zawn".
- Gave his used napkin to Improv Everywhere during one of their missions which involved them selling used celebrity trash in Times Square.
- Was considered for the role of Bishop in Juice (1992).
- Oldest of the three Faison boys, who include Dade and Olamide Faison.
- An alumnus of City Kids.
- His name Donald comes from the Gaelic name Domhnall meaning "ruler of the world", composed of the old Celtic elements dumno "world" and val "rule". This was the name of two 9th-century kings of the Scots and Picts.
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