- U.S. producers were so taken by her recurring guest role on TV's The Good Wife (2009), that she was asked to stay on during her pregnancy, with the series storyline specifically adapted to accommodate her growing bump.
- Dropped out of high school at age 16.
- In 1997, Melissa appeared topless in the Australian Playboy.
- Melissa is a talented roller skater who took home bronze medals in national competitions in 1989 and 1990 and a silver medal in 1991.
- Gave birth to her 1st child at age 37, a son Raphaël Blanc on February 6, 2014. Child's father is her now ex-boyfriend, Jean-David Blanc.
- Melissa George became the first celebrity to imprint her hands into Walk of Fame of Warner Bros. Movie World in Gold Coast, Australia. She signed it "Love always, Melissa George, 2008" in August 2008, while she was filming Triangle (2009).
- The only person to appear in both the original Australian version of The Slap (2011) and its American remake, The Slap (2015).
- Was an Australian national champion in rollerskating. She won bronze medals in the National Championships in 1989 and 1990 and a silver medal at the Junior World Championship in 1991.
- Melissa described her role in the psychological thriller, Triangle (2009), as one of the most difficult roles she has performed.
- She watched a 72-year-old man in Paris undergo heart surgery in the lead up to her new role on the NBC medical drama, Heartbeat (2016).
- Named Western Australia's teenage model of the year (1992).
- Was in a relationship with Jean-David Blanc from 2011 to 2016. They have two sons together.
- Melissa learned a bit of Portuguese for the movie, Turistas (2006).
- Divides her time between New York City and Paris.
- Gave birth to her 2nd child at age 39, a son Solal Samuel Glenn Blanc on November 3, 2015. Child's father is her now ex-boyfriend, Jean-David Blanc.
- Returned to work 2 weeks after giving birth to her son Raphael, in order to begin filming an untitled TV pilot, alongside Katie Holmes, which didn't get picked up later.
- Melissa made it to the list of Who magazine's World's Sexiest People of 2008.
- Was named one of People's 2016 World's Most Beautiful.
- She describes her French as "passable" - and says it's "getting better day by day".
- Best friends with Rachel Blanchard.
- She became a US Citizen in 2008.
- Melissa was a huge Grey's Anatomy (2005) fan, even before joining the cast for the show.
- Met her future now ex-husband Claudio Dabed on June 20, 1998, in Bali.
- Her parents are Pamela (a nurse) and Glenn George (a construction worker).
- She has two sisters named Marnie and Kate and one brother named Brett.
- Studied in Warwick Senior High School.
- Melissa claims that she was a class clown in high school.
- (June 5, 2015) Expecting her 2nd child with her boyfriend (now ex-boyfriend) Jean-David Blanc.
- Ex-husband Claudio Dabed is Chilean.
- Former stepdaughter, Martina Dabed, was born in 1995.
- Born on exactly the same date as Soleil Moon Frye (of "Punky Brewster" fame).
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