- Directed 8 actors to Oscar nominations: Frank Morgan (Best Actor, The Affairs of Cellini (1934)), Claudette Colbert (Best Actress, Private Worlds (1935)), William Powell (Best Actor, My Man Godfrey (1936)), Carole Lombard (Best Actress, My Man Godfrey (1936)), Mischa Auer (Best Supporting Actor, My Man Godfrey (1936)), Alice Brady (Best Supporting Actress, My Man Godfrey (1936)), Andrea Leeds (Best Supporting Actress, Stage Door (1937)), and Marjorie Rambeau (Best Supporting Actress, Primrose Path (1940)).
- He has a star on the Hollywood Walk of Fame located at 6906 Hollywood Blvd.
- Is portrayed by Allan Arbus in W.C. Fields and Me (1976).
- La Cava is reported to have believed that a script exists only to be ignored.
- He has directed two films that have been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: So's Your Old Man (1926) and My Man Godfrey (1936).
- Was a good friend and drinking buddy of W.C. Fields. La Cava's alcoholism ruined his career in the 1940s and contributed to his death just shy of his 60th birthday.
- Biography in: John Wakeman, editor. "World Film Directors, Volume One, 1890-1945." Pages 605-609. New York: The H.W. Wilson Company, 1987.
- Son William Morse La Cava (c. 1925).
- Step-son, Gil La Cava, still holds the High Jump school record after 81 years at Beverly Hills High School.
- Is interred with his mother at the Chapel of the Pines Crematory in Los Angeles, CA.
- In 1916, La Cava persuaded his art school friend Grim Natwick to join him at the Hearst cartoon studio for "a couple of weeks". Natwick became a legendary animator over a 60-year career, best known as the creator of Betty Boop.
- W.C. Fields said La Cava had "the best comedy mind in Hollywood".
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