- When asked by an interviewer in 1965 who she considered to be a great beauty, Brigitte Bardot said that in her opinion Virna Lisi was the most beautiful woman in the world.
- Was cast in the title role in Barbarella (1968), but she turned it down and returned to Italy.
- The '80s Argentinian band, Sumo (led by an Italian singer), made a song for her. The singer's brother is the actor Andrea Prodan, who appeared with her in the movie I ragazzi di via Panisperna (1988).
- Alternated filming activity with television and stage acting, namely at Piccolo Teatro di Milano, where she did "I giacobini" by Federico Zardi, under the direction of Strehler. She was one of the stars launched as a successor to Marilyn Monroe in the United States, in the late '60s.
- One child from Franco Pesci: Corrado, born in July 1962.
- She has three grandsons: Franco (b. 1995), Federico and Riccardo (b. 2003).
- Sister of actress Esperia Pieralisi, aunt of actress Stefania Graziosi.
- Sister-in-law of Franco Graziosi.
- Has a pilots licence.
- She was oiriginally a brunette but turned blonde.
- Is about 5ft 5 and weighs about 8 stone 10 lb.
- She made 30 films in Italy before being discovered by George Axelrod.
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