- Best friends with Whose Line Is It Anyway? (1998) co-star Ryan Stiles.
- Was appearing regularly on six different television shows at the same time.
- Is frequently mocked by his co-stars on Whose Line Is It Anyway? (1998) for his receding hairline, flamboyant shirts, and Canadian heritage.
- The "Hollywood Director" skit on the television show Whose Line Is It Anyway? (1998), in which Mochrie always plays the improv director of the other characters, is a reference to his real-life role directing the touring company at Second City Toronto, which he's done since 1996.
- Graduated as valedictorian from Killarney Secondary School in Vancouver. (1975)
- Can be seen in a couple of Nabisco commercials as the tutu-wearing Snack Fairy. (March 2005)
- Alumnus of Second City Toronto.
- Has been used many times as a star of or for cameo appearances in many internet Flash videos.
- Has become an internet meme, as amateur Flash animations called animutations often use images of him.
- Has a daughter, Kinley Mochrie, with Debra McGrath.
- He and Brad Sherwood are currently on tour doing their improvisation show. (November 2004)
- Is going to host "Are You Smarter Than a Canadian 5th Grader?". (2007)
- Uncle of Thomas Chambers and Munro Chambers.
- (1996-) Director of the touring company at Second City Toronto.
- Getting Along Famously (2006), a CBC pilot, with wife Debra McGrath, airs January 10, 2005. (January 2005)
- Is the actor/comedian present in many Mohegan Sun casino commercials.
- Bears a striking resemblance to actor Tom Noonan.
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