- Was considered for the role of Bindiya in Billu (2009) but it was then decided she looked too young to play a mother of two.
- Very close friends with actor Sanjay Dutt and his wife Maanayata.
- Turned down Bipasha Basu's role in Jism (2003).
- To prepare for her role as a prostitute in her film Paradise Street, she began chain smoking cigarettes and cigars heavily. She would have one to two packs a day and sometimes multiple cigars a day. She did this because she felt it would give her more feel to the role. However, now she finds smoking hard to stop and says she is addicted.
- After her infamous conflict with her parents, she changed the spelling of her name from Amisha to Ameesha which was initially a mix of both of her parents' names (Amit and Asha), as seen in the credits for Mangal Pandey: The Rising (2005). Later, she briefly dropped her surname from the credits for Thoda Pyaar Thoda Magic (2008). However, she has mended her relationship with her parents since.
- Daughter of Asha Patel and sister of Ashmit Patel
- Her favorite movies are Qayamat Se Qayamat Tak (1988), Dilwale Dulhania Le Jayenge (1995), Umrao Jaan (1981), Chandni (1989) and Pretty Woman (1990).
- Offered Kareena Kapoor's role in Chameli (2003).
- Turned down a job offer from Morgan Stanley for a career in Bollywood.
- Mother Asha Patel is also a actress. Her filmography is often mixed up with another older actress named Asha Patel. This is due to both having the same exact name.
- Starred in Vikram Bhatt's shelved film co starring her brother Ashmit Patil. The film was a thriller based on reincarnation Amisha was to die at the interval then be born as Ashmit in the next life time.
- Won gold medal for an Economics paper at her university.
- Dropped out of the role of Bhoomika Chawla in In Your Name (2003) due to scheduling conflicts.
- Trained Bharatnatyam dancer since the age of five.
- Supports NGOs such as PETA, Planet Read and UN for human trafficking to name a few.
- Was signed for Piyush Pandya (American Desi) movie "The Arranged Marriage" (2003). The film was to be shot in New Jersey. Amisha later opted out and Perizaad Zorabian replaced her. Starring Perizaad Zorabian, Ayesha Dharker, Ajay Naidu, Russel Peters.
- Obtained Biogenetic Engineering degree in the United States.
- Granddaughter of barrister politican, Rajni Patel.
- Economic graduate from Tufts University, Boston
- Attended Tufts University in Medford, Massachusetts. Studied Economics and graduated as part of the class of 1997.
- Acted in a play titled 'Neelam' in 1999.
- Worked as an economic analyst for Khandwala Securities Limited post-graduation.
- Studied at the Cathedral and John Connon School and was voted the head girl for the academic year 1992-1993.
- Starred in Shubi Mukherjee's shelved film " Dil Dekhe Dekho". Directed by Lawrence Dsouza, co starring Fardeen Khan,Sucheta and Farida Jalal.
- Starred in Tanuja Chandra shelved film opposite Karan Nath. This was in 2002.
- Starred in American director' Navraj Kaur's shelved film . This was in 2003. She was to play a actress names Zarina Khan from the 1930's.She was going to learn Kathak dancing from Birju Maharaj.
- Amisha Patel and brother Ashmit had been signed to do a film together. The Vikram Bhatt project was to have Amisha dying in the first half and reincarnate as a guy-Ashmit-to resolve the past. The project got shelved in 2004.
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