- Her stage name Eileen Ryan comes from her real first name Eileen and her mother's maiden name Ryan.
- Appeared with her sons Sean Penn and Chris Penn in At Close Range (1986), in which she portrayed their grandmother.
- She is the daughter of Rose Isabel (Ryan) and Amerigo/Americus Giuseppe/William Annucci. She is of half Italian and half Irish descent.
- First met the recently divorced Leo Penn in 1957 during rehearsals for a Circle in the Square production of The Iceman Cometh in New York.
- Former mother-in-law of Madonna and Robin Wright.
- Made her Broadway debut in 1953 in Sing Till Tomorrow.
- Grandmother of Dylan Penn and Hopper Penn.
- Often appears in films directed by and/or starring her son, Sean Penn.
- Mother-in-law of Aimee Mann.
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