- Isn't a huge fan of classic rock music. He wrote School of Rock (2003) specifically so Jack Black could perform his own favorite rock music.
- Son of Mel White. Until the early 1990s. Mel White was a speech and ghostwriter for such evangelical, far-right Christian figures as Jerry Falwell, Pat Robertson and Billy Graham. When Mel finally accepted his long-repressed homosexuality, he and his wife, Lyla, divorced amicably and Mel started a gay-rights organization called "Soulforce". Mike's mother, Lyla, later became executive director of the historic performing arts venue, Pasadena Playhouse in Pasadena, California.
- He got his first impulse toward writing scripts from his favorite teacher in second grade, the mother of playwright Sam Shepard.
- He and Jack Black formed a production company called Black and White.
- Is a two-time amazing race contestant with his father Mel. The first time they competed they lasted for seven legs and were eliminated in sixth place. The second time they competed they only lasted two legs and were in tenth place.
- In September 2018, he was the runner up on Season 37 of "Survivor: David vs. Goliath".
- His ancestry includes English, as well as Norwegian, German and Swedish.
- Born on the exact same date as Steve Burton.
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