- His favorite character on The Big Bang Theory (2007) is Penny.
- Voted friendliest in his high school graduating class.
- He was awarded a Star on the Hollywood Walk of Fame for Television at 6533 Hollywood Boulevard in Hollywood, California on March 11, 2015.
- Is prone to motion sickness. Riding in a car will make him nauseated so he prefers to drive.
- Standing 6' 1", is by far the tallest principal cast member on The Big Bang Theory (2007). None of the other regular cast are taller than 5' 7".
- Said in 2016 that he would love to play The Joker in a future "Batman" film.
- His mother, Judy Parsons, is a first grade teacher and his father, who passed away in a car accident in 2001, was the president of a plumbing company. His younger sister, Julie Parsons, is also a teacher. Judy and Julie work at the same school, and have shared a classroom.
- Owns a production company, That's Wonderful Productions, with his partner, Todd Spiewak.
- Received his Master of Fine Arts degree in Acting from the Old Globe Theatre/University of San Diego's Professional Training Program (2001).
- When Parsons married Todd Spiewak in May 2017, they had been romantic partners for 14 years.
- His early influence was Johnny Carson.
- Took piano classes for 14 years.
- Made his Broadway debut in 2011 as Tommy Boatwright in "The Normal Heart".
- In May 2012, The New York Times reported that Parsons is gay and at the time had been in a relationship for the last ten years.
- Received his 2010-2011 Golden Globe from Matt Bomer, a fellow graduate of the Klein Independent School District. Parsons graduated from Klein Oak, Bomer from Klein High School.
- Received an undergraduate degree in Theatre from the School of Theatre and Dance at the University of Houston (1996).
- His favorite series are The Mary Tyler Moore Show (1970), Three's Company (1976), Family Ties (1982) and The Cosby Show (1984).
- His character Sheldon Cooper is a Star Trek fan,but he has never seen Star Trek in real life.
- He played a bird in his first school play in elementary school.
- Worked for Microsoft Sidewalk in Houston as an assistant for Megan Halverson.
- Has English, French, German and Scottish ancestry.
- Paid $8.35 million to purchase 4 apartments at 36 Gramercy Park East in New York City.
- His theatrical credits include "Endgame", "Guys and Dolls", "What Happened Was" and "The Balcony".
- Attended and graduated from Klein Oak High School in Spring, Texas (1991).
- Was a member of Infernal Bridegroom Productions, a Houston-based theater company.
- Husband Todd Spiewak is a graphic designer/art director.
- He has never seen any Star Trek related movies and shows before playing Sheldon Cooper.
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