Jack Nicholson, Michelle Pfeiffer, Susan Sarandon, and Cher at an event for The Witches of Eastwick (1987)
Susan Sarandon, Cher and Michelle Pfeiffer as The Witches of Eastwick
To be eligible, it has to be a female trio (no quartet) and they have to be the lead of their respective movie/show, or the main female protagonists.