Lou Costello didn't want to make the movie, declaring, "No way I'll do that crap. My little girl could write something better than this." A $50,000 advance in salary and the signing of director Charles Barton, the team's good friend and the man some call their best director, convinced him otherwise.
Although he would play similar vampires, ghouls, zombies, et al, in other films since Dracula (1931), this would be only the second, and last, time that Bela Lugosi would play Dracula in a feature film.
The scene in which Wilbur unknowingly sits on the Frankenstein monster's lap required multiple takes. Lou Costello improvised wildly, causing Glenn Strange to break up laughing constantly during takes.
When trying to seduce Wilbur, Sandra says that he is," . . . so round, so firm . . . " and Wilbur says, "So fully packed." This is making fun of the slogan for Lucky Strike cigarettes, which was one the most pervasive taglines in the history of advertising. Beyond this, a song using the same tagline the previous year was a major hit for Merle Travis as well as a couple of popular cover versions.