Karen was originally part of a 3 show 90 minute programming block called 90 Bristol Court. It originally contained 3 sitcoms, that had completely different casts and crews but they All lived under the same apartment complex, with the address of 90 Bristol Court. The other two sitcoms that made up the rest of the block were Tom Dick and Marry and Harris Against the World. NBC's experiment for the 1964-65 season flopped miserably due to it's tough competition (it was up against three powerhouse CBS shows, To Tell The Truth, I've Got A Secret and Andy Griffith) and the show didn't receive the best reviews from critics at the time and all three of the shows couldn't get a stable audience to continue to the next season.
Sooner or later, the concept of 90 Bristol Court was dropped, Harris Against the World and Tom Dick and Marry were canceled Mid Season while Karen managed to finish the season. Karen probably was the best out of all three shows that made up 90 Bristol Court but the concept of Karen by itself doesn't seem very interesting to me (other teenage girl shows from that era were probably better, Like Patty Duke or Gidget). In fact, I think the whole concept of 90 Bristol court sounds better than Karen by itself, but I guess I'll never know, unless the shows gets put on DVD or in syndication (in which that probably won't happen).