If you look at the poster currently shown on IMDb for this film, you'd think the film is about zombies and nubile creatures running about in various states of undress. Well, if that's what you're looking for, then "Die Sister, Die!" is not the film for you. Despite the poster, the film is a murder mystery--and the solution to the mystery isn't all that difficult to deduce. But, it does set a nice, spooky mood--so it is worth a look.
The film begins with a crazy old lady trying to kill herself. She is saved but the doctor (Kent Smith) talks to her brother about either committing her or getting someone to look after her and make sure this doesn't happen again. The loving brother isn't so loving and finds someone--someone he assumes will do nothing to stop the sister from killing herself next time. Then, it seems, he'll inherit the family fortune. Why he hates her and why she hates herself is something you'll soon learn in this spooky but not especially deep film. It really sets a nice mood but that is all. A bit obvious but enjoyable nonetheless.