The actresses consumed over 100 cheesecakes during the show's seven-year run. Bakeries from around the USA would send in cheesecakes for them. Bea Arthur hated cheesecake in real life.
It was not originally scripted for Blanche to have a Southern accent. Instead, it was Rue McClanahan's idea to introduce it.
When the show first aired, Queen Elizabeth the Queen Mother loved it so much that she wrote to the four actresses and asked them to perform a live show especially for her. They obliged, and acted out a sketch during the The Royal Variety Performance 1988 (1988), at which the Queen Mother was present, in which the girls are depicted onstage visiting London, first interacting with the host Ronnie Corbett and then sitting down for dinner, recreating various moments from previous episodes.
Throughout the series, there are many jokes made by the girls, at Rose's expense, regarding her natural hair color. Betty White was in fact a natural brunette and dyed her hair blonde.
Estelle Getty underwent a face-lift between the first and second seasons, much to the horror of the make-up crew who already had to go to great lengths to make Getty look older on camera.