The Oprah Winfrey Show

It's amazing media empire that Winfrey has built - including print, film, and television - starting from this show. While the quality has varied over the years, and some might not be a fan of the "touchy-feely" bent many of the shows have taken over the past few years, Oprah is a remarkably likeable, real, and charismatic figure. She has appealed to a wide audience, and has often chosen the hight road when making programming decisions. The show has definitely been a positive force in North America - the effect of "Oprah's Book Club" on book sales alone is proof of that - and hopefully will continue to be for years to come.