Several of the cast and crew were covered in poison ivy throughout the filming of the movie, this was due to the chairs being placed in what was first thought to be a group of weeds only later to be discovered as a patch of the rash causing plants.
Emmanuelle Chriqui dislocated her shoulder performing her fall through the trees. You can hear her shoulder pop on the production track in the theatrical sound mix.
The female lead character, Jessie Burlingame, was named after the heroine in Stephen King's novel, "Gerald's Game".
Unlike the sequels, this first movie doesn't have any nudity. There were attempts to include some nude and sex scenes typical for the genre, when writers like Adam Cooper, Bill Collage and others were working on different versions of the scripts. For example, opening was changed and had Rich and Halley bathing nude in river before being killed while having sex on land, Francine and Evan having sex in woods and not near their crashed cars, Jessie's clothes being torn off from her while she's tied to the bed, and more similar scenes which weren't kept at all in the film.