According to the clues of Hal, played by Jake Gyllenhaal, the proof can be the proof of Riemann hypothesis. He says "a very important proof, of a mathematical theorem about prime numbers, which mathematicians are trying to prove; it's historic; you can publish it, give press conferences; all newspapers in the world will talk to the person who have found it." It's one of the Millennium Problems.
Gwyneth Paltrow presented Mary-Louise Parker with the Tony Award for Best Actress in a Play for her performance in the Broadway version of "Proof".
David Auburn's play "Proof" premiered at the Manhattan Theater Club, in New York City, in May 2000. On October 24, 2000, it moved to the Walter Kerr Theater, where it ran for nine hundred seventeen performances. "Proof" won the 2001 Tony Award for the Best Play, and the Pulitzer Prize in Drama the same year.