Rex is a regular teenager, except he has nanites that he can control. He works for Providence to help contain people who have been infected by nanites and are raging out of control.
Nanite activity is increasing around the world. Rex decides to go to one area for Spring Break. He befriends a lonely young woman with a secret agenda.
Rex hides from Providence. He encounters a group of scientists that have created a hidden community. The community doesn't realize what the creator had it mind when he built the community.
Rex vanishes, and Breach is the only person who knows where he is. As Rex explores his surroundings, Holiday tries to figure out where Breach has him hidden.
A Providence team retrieving some valuable data is shot down over Kiev, which has been sealed off from the rest of the world. Rex, Six, and Bobo must enter the dome to retrieve the data, and encounter the inhabitants.
Rex encounters a group of Evos, and discovers a link to his past. He goes undercover to take down the leader of the group, and learns more about his past, and how it could affect his current life.
Researchers test a new way to eliminate nanites, but the results are not successful. Zag RS emerges and plans on using the method to destroy all the nanites. Rex must journey to a satellite to rescue Holiday and stop Zag RS.
Rex receives an urgent call from Circe. Abysus is in danger, and they desperately need Rex's help. Rex, Holiday and Six go to Abysus to find out what's going on. Rex balks when he realizes what will happen if he helps the Pack.
An Evo plague is spreading. People are falling asleep. Rex and White Knight are the only one left to stop the plague. They must work together to find the source of the plague.
Van Kleiss steals Rex's nanites which powers up Van Kleiss and Rex powerless. Van Kleiss gains new abilities and attacks Providence. Meanwhile Rex tries to get his power back and finds something in his system.
