Like almost every tv/movie adaptation of a book this is very much not recommended for book purist. Although it is brilliant the show takes a lot of liberties with the source material. Sometimes out of necessity and sometimes to tell a particular story. Upping the age of Claudia from a young child to a tween was done out of necessity so the show could tell a story about her without feeling icky about it. While making Louis black and gay, born during Jim Crow In New Orleans was a way to add pathos to the character. Making the series both acknowledge the movie but then hand wave it was an interesting choice as well. Daniel Molloy the interviewer is older now and more aware of the danger he is in but still curious about why Louis wants to retell the story he only partly told before. The Interview scenes are some of the most fascinating scenes of the series for me.
And then there is Lestat. Lestat the vampire who is very hard to explain so I won't even try. He alone is worth watching this series for.