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ADAMTS12 promotes fibrosis and enables activation of injury-responsive fibroblasts
In this episode, Rafael Kramann, Konrad Hoeft, and Lars Koch explain that catalytically active ADAMTS12 controls fibrosis by restructuring ECM to enable activation and migration of a distinct injury-responsive fibroblast subset after injury...
Published September 17, 2024
Author's Take
Sex- and age-specific differences revealed by mouse sarcopenia models
In this episode, Jose Garcia and Haiming Kerr describe how their study characterizes sarcopenia in aged mice using a clinically relevant definition, elucidating age-related changes in muscle mass and function...
Published August 15, 2024
Author's Take
Tet2 function and innate immune resistance to bacterial pneumonia
In this episode, Candice Quin explains how individuals with TET2-mutant CHIP are at increased risk of bacterial pneumonia due to innate immune impairments...
Published July 17, 2024
Author's Take
JCI’s Conversations with Giants in Medicine: Stanley Prusiner
In this episode, Ushma Neill talks with Dr. Stanley Prusiner. The discovery that a protein alone could be infectious, proposed by Stanley Prusiner of the University of California San Francisco, was considered heretical in 1982. Now considered orthodoxy...
Published July 15, 2024
Conversations with Giants in Medicine
Prolonged transplant survival in preclinical models
In this episode, Leonardo Riella presents his manuscript detailing how a humanized mutein IL-2 selectively expands and boosts the function of mouse, non-human primate and human regulatory T cells, prolonging allograft survival...
Published April 24, 2024
Author's Take
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