KEGG ENZYME: 1.4.3.22

ENZYME: 1.4.3.22

Entry

EC 1.4.3.22                 Enzyme

Name

diamine oxidase;
amine oxidase (ambiguous);
amine oxidase (copper-containing) (ambiguous);
CAO (ambiguous);
Cu-containing amine oxidase (ambiguous);
copper amine oxidase (ambiguous);
diamine oxidase (ambiguous);
diamino oxhydrase (ambiguous);
histaminase;
histamine deaminase (incorrect);
semicarbazide-sensitive amine oxidase (incorrect);
SSAO (incorrect)

Class

Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor

Sysname

histamine:oxygen oxidoreductase (deaminating)

Reaction(IUBMB)

histamine + H2O + O2 = (imidazol-4-yl)acetaldehyde + NH3 + H2O2 [RN:R02150]

Reaction(KEGG)

R02150;
(other) R01151 R02173 R03139 R04674 R05334

Substrate

histamine [CPD:C00388];
H2O [CPD:C00001];
O2 [CPD:C00007]

Product

(imidazol-4-yl)acetaldehyde;
NH3 [CPD:C00014];
H2O2 [CPD:C00027]

Comment

A group of enzymes that oxidize diamines, such as histamine, and also some primary monoamines but have little or no activity towards secondary and tertiary amines. They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, like EC 1.4.3.21 (primary-amine oxidase) but unlike EC 1.4.3.4 (monoamine oxidase), they are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide.

History

EC 1.4.3.22 created 2007 (EC 1.4.3.6 created 1961, part-incorporated 2008)

Pathway

ec00330

Arginine and proline metabolism

ec00340

Histidine metabolism

ec00380

Tryptophan metabolism

ec01100

Metabolic pathways

Orthology

K11182

diamine oxidase

Genes

HSA:

26(AOC1)

PTR:	107975990(AOC1)

PPS:	100973977(AOC1)

GGO:	101145709(AOC1)

PON:	100173768(AOC1)

PPYG:

129040616(AOC1)

NLE:	100598250(AOC1)

HMH:	116814531(AOC1)

SSYN:

129485201(AOC1)

MCC:	714112(AOC1)

MCF:	102141942(AOC1)

MTHB:

126951582

MNI:	105474898(AOC1)

CSAB:

103227226(AOC1)

CATY:

105584732(AOC1)

PANU:

101022639(AOC1)

TGE:	112620088(AOC1)

MLEU:

105542715(AOC1)

RRO:	104675391(AOC1)

RBB:	108531161(AOC1)

TFN:	117072053(AOC1)

PTEH:

111551462(AOC1)

CANG:

105511320(AOC1)

CJC:	100414302(AOC1)

SBQ:	101033597(AOC1)

CIMI:

108297805(AOC1)

ANAN:

105710757(AOC1)

CSYR:

103249599(AOC1)

MMUR:

105883171(AOC1)

LCAT:

123647521(AOC1)

PCOQ:

105824630(AOC1)

OGA:	100957748(AOC1)

MMU:	243376(Aoc1l1) 243377(Aoc1l3) 69761(Aoc1l2) 76507(Aoc1)

MCAL:

110296626 110296761 110296945 110297026

MPAH:

110316605 110316610 110317089 110317172

RNO:	297081(Svs1) 312316(Doxl1) 312317(Doxl2) 65029(Aoc1)

MCOC:

116098863 116098864 116098865 116098866

ANU:	117720742 117720825 117720826

MUN:	110551277 110551279 110551298

CGE:	100763954 100771382

MAUA:

121138472

PROB:

127235626(Aoc1) 127235671 127235673

PLEU:

114700050 114700051 114700052 114700053

MORG:

121439935 121440030 121440036

MFOT:

126491149 126491168 126491170 126491174

AAMP:

119807353 119807862 119807867 119807917

NGI:	103745300 103745301 103745358 103745360 103745361

HGL:	101712557(Aoc1)

CPOC:

100735646(Aoc1)

CCAN:

109694449(Aoc1)

DORD:

105993860(Aoc1)

DSP:	122105942(Aoc1)

PLOP:

125345903(Aoc1)

NCAR:

124991550

MMMA:

107148941(Aoc1)

OCU:

100347103

OPI:	101521505(AOC1)

TUP:	102495583(AOC1)

GVR:	103585108(AOC1)

CFA:	475536(AOC1)

CLUD:

112663912(AOC1)

VVP:	112916289(AOC1)

VLG:	121490161(AOC1)

NPO:	129515628(AOC1)

AML:	100484243(AOC1)

UMR:	103660997(AOC1)

UAH:	113241424(AOC1)

UAR:	123789633(AOC1)

ELK:

111154511

LLV:

125081368

MPUF:

101676852(AOC1)

MNP:	132014856(AOC1)

MLK:	131829933(AOC1)

NVS:	122904177(AOC1)

ORO:	101381594(AOC1)

EJU:	114198028(AOC1)

ZCA:	113910982(AOC1)

MLX:	118026779(AOC1)

NSU:	110582923(AOC1)

LWW:	102735661(AOC1)

FCA:	101096221(AOC1)

PYU:	121022919(AOC1)

PCOO:

112866890(AOC1)

PBG:	122488525(AOC1)

PVIV:

125160926(AOC1)

LRUF:

124522887

PTG:	102955637(AOC1)

PPAD:

109252362(AOC1)

PUC:

125931025

AJU:

106974449

HHV:	120230887(AOC1)

BTA:	509751(AOC1)

BOM:	102275498(AOC1)

BIU:	109557791(AOC1)

BBUB:

102401037(AOC1)

BBIS:

105001109(AOC1)

CHX:	102177774(AOC1)

OAS:	101112561(AOC1)

BTAX:

128046665(AOC1)

ODA:	120877884(AOC1)

MREE:

136170868(AOC1)

MBEZ:

129552777(AOC1)

SSC:	100517436(AOC1)

CFR:	102522082(AOC1)

CBAI:

105080841(AOC1)

CDK:	105105709(AOC1)

VPC:	102536442(AOC1)

BACU:

103017288(AOC1)

BMUS:

118900903(AOC1)

LVE:	103087882(AOC1)

OOR:	101279845(AOC1)

DLE:	111182632(AOC1)

PCAD:

102985231(AOC1)

PSIU:

116759874(AOC1)

NASI:

112405919(AOC1)

ECB:	100063930(AOC1)

EPZ:	103544966(AOC1)

EAI:	106823380(AOC1)

MYB:	102256259(AOC1)

MYD:	102751704 102773146

MMYO:

118679433 118679451

MLF:	102429483 102429790 102437933 102438245

MDT:	132242622(AOC1) 132242623

PKL:	118704793 118704794

EFUS:

103301763

MNA:	107524935(AOC1)

DRO:	112308354(AOC1)

SHON:

118975541(AOC1)

AJM:	119039221(AOC1)

PDIC:

114508131(AOC1)

PHAS:

123817970(AOC1)

MMF:	118620405(AOC1)

PPAM:

129086742(AOC1)

HAI:	109389675(AOC1)

RFQ:	117017972(AOC1)

PALE:

102880369(AOC1)

PGIG:

120601491(AOC1)

PVP:	105309118(AOC1)

RAY:	107520313(AOC1)

MJV:	108391836(AOC1)

TOD:	119248227 119251584(AOC1)

SARA:

101546506(AOC1)

SETR:

126002942(AOC1)

LAV:	100668068 100668351(AOC1)

TMU:

101356291

ETF:	101644129(AOC1)

DNM:	101432392(AOC1)

MDO:	100017902(AOC1)

GAS:	123249248(AOC1)

SHR:	100915360(AOC1)

AFZ:

127564613

PCW:	110201979(AOC1)

TVP:	118852055(AOC1)

OAA:	100075142 100092837

GGA:	100858159(AOC1)

PCOC:

116242830(AOC1)

CJO:	107308680(AOC1)

TPAI:

128086210(AOC1)

LMUT:

125696091(AOC1)

NMEL:

110390704(AOC1)

ACYG:

125180892(AOC1)

CATA:

118251768(AOC1)

AFUL:

116486715(AOC1)

TGU:	115494067(AOC1)

LSR:	110475119(AOC1)

PMOA:

120510541(AOC1)

OTC:	121334879(AOC1)

PRUF:

121356980(AOC1)

FAB:

101814988

OMA:	130250363(AOC1)

PHI:	102101625(AOC1)

PMAJ:

107214654(AOC1)

ZLE:	135443488(AOC1)

SVG:	106861806(AOC1)

MMEA:

130574567(AOC1)

FPG:	101917962(AOC1)

FCH:	102057016(AOC1)

SHAB:

115610906(AOC1)

ACUN:

113477547(AOC1)

ACHC:

115338959(AOC1)

HLE:	104829369(AOC1)

AGEN:

126037598

AFOR:

103896035

CLV:	102084607(AOC1)

RTD:	128904801(AOC1)

AAM:

106500478

AROW:

112973601(AOC1)

NPD:	112956255(AOC1)

DNE:	112994715(AOC1)

ASN:	102380706(AOC1)

AMJ:	102569229(AOC1)

CPOO:

109305661(AOC1)

CMY:	119565483(AOC1)

CCAY:

125632975(AOC1)

DCC:	119850720(AOC1)

CPIC:

101932586(AOC1)

CABI:

116826256(AOC1)

MRV:	120397756(AOC1)

ACS:	100557987(aoc1)

ASAO:

132779098(AOC1)

PVT:	110082530(AOC1)

SUND:

121932802(AOC1)

PBI:	103060423(AOC1)

PMUR:

107299028(AOC1)

CTIG:

120320272(AOC1)

TSR:	106538995(AOC1)

PGUT:

117669219(AOC1)

APRI:

131196512(AOC1)

NSS:

113432327

VKO:	123019558(AOC1)

PMUA:

114607277(AOC1) 114607667

PRAF:

128424002 128424003

ZVI:	118092275(AOC1)

HCG:	128329352(AOC1)

GJA:	107108215(AOC1)

STOW:

125441204(AOC1)

EMC:	129337721(AOC1)

XLA:	108695581(aoc1.S) 108705560 121394786

XTR:	100486601(aoc1)

NPR:	108803230(AOC1)

RTEM:

120941749(AOC1)

BBUF:

121000742 121000746

BGAR:

122939047 122939163

MUO:	115465224(AOC1)

GSH:	117354471(AOC1)

DRE:	555401(aoc1)

SRX:	107713450 107753085

SANH:

107667202 107687273

SGH:	107553388 107574283

CCAR:

109050071(aoc1) 109066974

CAUA:

113042653 113068779

CGIB:

127946561 128012934

PTET:

122329405(aoc1)

LROH:

127155451(aoc1)

OMC:	131533599(aoc1)

PPRM:

120467772 120467773 120467774 120467781(aoc1)

RKG:	130070551(aoc1)

MAMB:

125258191(aoc1)

CERY:

137013972(aoc1)

MASI:

127431507 127434807

TROS:

130546697 130547122

TDW:	130412847(aoc1)

MANU:

129426389(aoc1)

IPU:

108276865

IFU:	128614235(aoc1)

PHYP:

113526925(aoc1)

SMEO:

124383752(aoc1)

TFD:	113644436(aoc1)

TVC:	132845586(aoc1)

TRN:	134310465(aoc1)

AMEX:

103033242(aoc1)

CMAO:

118820971(aoc1)

EEE:	113573000(aoc1)

CHAR:

105890196(aoc1)

TRU:	101078662(aoc1)

TFS:	130513890(aoc1)

TNG:	GSTEN00016700G001

LCO:	104927590(aoc1)

NCC:	104965259(aoc1)

TBEN:

117479624(aoc1)

CGOB:

115025641(aoc1)

PGEO:

117465520(aoc1)

GACU:

117558299(aoc1)

EMAC:

134883909(aoc1)

ELY:	117264363(aoc1)

EFO:	125881975(aoc1)

PLEP:

121960670(aoc1)

SLUC:

116048943(aoc1)

ECRA:

117937727(aoc1)

ESP:	116672336(aoc1)

PFLV:

114548835 114549419

GAT:	120811880(aoc1)

PPUG:

119198447(aoc1)

AFB:	129111028(aoc1)

CLUM:

117749755(aoc1)

PSWI:

130191504(aoc1)

CANA:

137788993(aoc1)

CVE:	137871686(aoc1)

MSAM:

119899852 119899859 119899864 119906205(aoc1) 119913472

SCHU:

122866578(aoc1)

CUD:	121527017(aoc1)

ALAT:

119008442(aoc1)

ASTR:

137587654(aoc1)

MZE:	101467347(aoc1)

ONL:	100696662(aoc1)

OAU:	116331837(aoc1)

OLA:	101163530(aoc1)

OML:	112151334(aoc1)

CSAI:

133423563(aoc1)

XMA:	102236337(aoc1)

XCO:	114136404(aoc1)

XHE:	116711418(aoc1)

PRET:

103482350(aoc1)

PFOR:

103143938(aoc1)

PLAI:

106938000(aoc1)

PMEI:

106915179(aoc1)

GAF:	122824085(aoc1)

PPRL:

129364898(aoc1)

CVG:	107086520(aoc1)

CTUL:

119791859(aoc1)

GMU:	124857735(aoc1)

NFU:	107382765(aoc1)

KMR:	108246408(aoc1)

ALIM:

106528598(aoc1)

NWH:	119426645(aoc1)

AOCE:

111562815(aoc1)

MCEP:

125024411(aoc1)

CSEM:

103376876(aoc1)

POV:	109629489(aoc1)

HHIP:

117753890(aoc1)

HSP:	118098734(aoc1)

PPLT:

128425488(aoc1)

SMAU:

118291412(aoc1)

LCF:

108881560

SDU:	111228279(aoc1)

SLAL:

111657042(aoc1)

XGL:	120789767(aoc1)

HCQ:	109518117(aoc1)

SSCV:

125986151(aoc1)

SBIA:

133493021(aoc1)

PEE:	133396634(aoc1)

PTAO:

133470132(aoc1)

BPEC:

110165585(aoc1)

MALB:

109953334(aoc1)

BSPL:

114854500(aoc1)

SJO:	128382217(aoc1)

SASA:

106590278

STRU:

115149506 115195631

OTW:	112216529 112227831

OMY:	110489795(aoc1) 110535211

OGO:	123990292 124039670(aoc1)

ONE:	115104538 115130247

OKI:	109899365 109908743

OKE:	118371680(aoc1) 118382767

SALP:

111953200 111972976

SNH:	120027726 120050370(aoc1)

CCLU:

121569139

ELS:	105019484(aoc1)

SFM:	108935426(aoc1)

PKI:	111840061(aoc1)

AANG:

118226141(aoc1)

LOC:	102689197(aoc1)

PSPA:

121312820 121314292

ARUT:

117435824(aoc1)

PSEX:

120529743(aoc1)

LCM:	102354448(AOC1)

RTP:	109924491(aoc1)

CPLA:

122546222(aoc1)

HOC:	132815262(aoc1)

LERI:

129696092(aoc1)

PMRN:

116938772 116938773 116938775 116938776 116938887

LRJ:	133345887 133345892 133345893

BFO:	118408402 118417782 118417844 118418228 118418426

BBEL:

109473389 109473390 109473691 109473692 109473966 109475039

LGI:	LOTGIDRAFT_118163 LOTGIDRAFT_118238 LOTGIDRAFT_120790 LOTGIDRAFT_133255 LOTGIDRAFT_137098 LOTGIDRAFT_159693 LOTGIDRAFT_159859 LOTGIDRAFT_224288

PVUL:

126816817 126817363 126817364 126819690 126819693 126820492 130010371

PCAN:

112553730 112554426 112554427 112554474 112572350

BGT:	106051633 106051897 106051898 106055791 106065387 106072430 106074955 106079478

GAE:	121366314 121368131 121376554 121379177 121383343 121388690

HRF:	124113939 124117460 124117462 124117463 124117472 124117480 124123687 124146804 124146827 124149720

HRJ:	124253577 124255670 124261729 124262034 124262226 124288962 124288964 124289009 124290976 124290998

HASI:

137261209 137266087 137277180 137277182 137277608 137277609 137278690 137278691 137279244 137279282 137298959

CRG:	105317726 105317731 105319659 105333031 105336069 105338020 105344412 117683425

CANU:

128162365 128163845 128176382 128181948

CVN:	111113942 111115458 111115981 111128807 111129375 111130229 111137669

OED:	125649361 125650946 125650947 125651284 125657531 125677240

MYI:	110451868 110456357 110456359 110456366 110456370 110458341 110463954

PMAX:

117334092 117334093 117334094 117334729 117334774 117334905 117335048 117339064

MMER:

123523139 123524764 123532570 123538506 123559568 123559569 123566673 123566674 128559541

RPHI:

132713293 132730567 132731808 132738652 132740090 132750347 132750840 132751349 132751364 132753015

DPOL:

127833438 127834717 127860907 127862483 127862519 127862527 127871114 127874330 127878945 127880334 127880335 127880336

MAEA:

128202977 128210348 128210358 128226535 128227829 128228415 128229832 128230466 128230483 128231785 128246449 128246725

OBI:	106869685 106870602 106880971

OSN:	115220554 115226162 115229303

LJP:	135472821 135472865 135473041 135473378 135473627 135473628 135473671 135473824

LAK:	106153941 106161605 106162659 106164094 106169091 106175867 106179266 106181241

SMM:	Smp_017610

SHX:	MS3_00004144(ABP1_1)

OVI:	T265_13327 T265_15957

EGL:

EGR_03941

LLON:

135501014

NVE:	116612167 116614151 5506426 5506432 5512395

EPA:	110238468 110241103 110247868 110247869 110247923 110247925 110247926

ATEN:

116304360 116307723 116308551 116308554

ADF:	107333816 107333827 107337677 107352948

AMIL:

114956446 114960919 114962028 114962043

PDAM:

113675191 113677914 113679149 113679167

SPIS:

111322076 111327136 111327159

DGT:	114527068 114527069 114527154 114527237

HSY:	130623856 130628787 130628788 130628980

RES:	135692230 135693617 135693686

CRE:	CHLRE_13g572750v5

MNG:

MNEG_1864

CSL:	COCSUDRAFT_46300

ACAN:

ACA1_076120

TGO:	TGME49_286782

FCY:	FRACYDRAFT_244491

» show all

Reference

Authors

Zeller EA.

Title

Diamine oxidases.

Journal

In: Boyer PD, Lardy H, Myrback K (eds). The Enzymes. 2nd ed. Vol. 8. New York: Academic Press; 1963. p. 313-335.

Reference

2 [PMID:182134]

Authors

Crabbe MJ, Waight RD, Bardsley WG, Barker RW, Kelly ID, Knowles PF.

Title

Human placental diamine oxidase. Improved purification and characterization of a copper- and manganese-containing amine oxidase with novel substrate specificity.

Journal

Biochem J 155:679-87 (1976)
DOI:10.1042/bj1550679

Reference

3 [PMID:8182053]

Authors

Chassande O, Renard S, Barbry P, Lazdunski M

Title

The human gene for diamine oxidase, an amiloride binding protein. Molecular cloning, sequencing, and characterization of the promoter.

Journal

J Biol Chem 269:14484-9 (1994)

Sequence

[hsa:26]

Reference

4 [PMID:10668504]

Authors

Houen G.

Title

Mammalian Cu-containing amine oxidases (CAOs): new methods of analysis, structural relationships, and possible functions.

Journal

APMIS Suppl 96:1-46 (1999)

Reference

5 [PMID:12072962]

Authors

Elmore BO, Bollinger JA, Dooley DM.

Title

Human kidney diamine oxidase: heterologous expression, purification, and characterization.

Journal

J Biol Inorg Chem 7:565-79 (2002)
DOI:10.1007/s00775-001-0331-1

Other DBs

ExplorEnz - The Enzyme Database:

1.4.3.22

IUBMB Enzyme Nomenclature:

1.4.3.22

ExPASy - ENZYME nomenclature database:

1.4.3.22

BRENDA, the Enzyme Database:

1.4.3.22

LinkDB

DBGET integrated database retrieval system