KEGG ENZYME: 1.4.9.2

KEGG

ENZYME: 1.4.9.2

Entry

EC 1.4.9.2                  Enzyme

Name

aralkylamine dehydrogenase (azurin);
aromatic amine dehydrogenase;
arylamine dehydrogenase;
tyramine dehydrogenase;
aralkylamine:(acceptor) oxidoreductase (deaminating)

Class

Oxidoreductases;
Acting on the CH-NH2 group of donors;
With a copper protein as acceptor

Sysname

aralkylamine:azurin oxidoreductase (deaminating)

Reaction(IUBMB)

ArCH2NH2 + H2O + 2 azurin = ArCHO + NH3 + 2 reduced azurin

Reaction(KEGG)

(other) R02382 R02612 R04300

Substrate

ArCH2NH2;
H2O [CPD:C00001];
azurin

Product

ArCHO;
NH3 [CPD:C00014];
reduced azurin [CPD:C05358]

Comment

Phenazine methosulfate can act as acceptor. Acts on aromatic amines and, more slowly, on some long-chain aliphatic amines, but not on methylamine or ethylamine

History

EC 1.4.9.2 created 1986 as EC 1.4.99.4, transferred 2011 to EC 1.4.9.2

Pathway

Tyrosine metabolism

Phenylalanine metabolism

Isoquinoline alkaloid biosynthesis

Metabolic pathways

Biosynthesis of secondary metabolites

Orthology

aralkylamine dehydrogenase light chain

aralkylamine dehydrogenase heavy chain

Genes

AFA:	UZ73_08875 UZ73_08890

AFQ:	AFA_01705 AFA_01720

D3M96_01565 D3M96_01580

Reference

1 [PMID:6830237]

Authors

Iwaki M, Yagi T, Horiike K, Saeki Y, Ushijima T, Nozaki M.

Title

Crystallization and properties of aromatic amine dehydrogenase from Pseudomonas sp.

Journal

Arch Biochem Biophys 220:253-62 (1983)
DOI:10.1016/0003-9861(83)90408-3

Reference

2 [PMID:7547967]

Authors

Hyun YL, Davidson VL

Title

Electron transfer reactions between aromatic amine dehydrogenase and azurin.

Journal

Biochemistry 34:12249-54 (1995)
DOI:10.1021/bi00038a020

Reference

3 [PMID:10506161]

Authors

Hyun YL, Zhu Z, Davidson VL

Title

Gated and ungated electron transfer reactions from aromatic amine dehydrogenase to azurin.

Journal

J Biol Chem 274:29081-6 (1999)
DOI:10.1074/jbc.274.41.29081

Reference

4 [PMID:15234267]

Authors

Davidson VL

Title

Electron transfer in quinoproteins.

Journal

Arch Biochem Biophys 428:32-40 (2004)
DOI:10.1016/j.abb.2004.03.022

Reference

5 [PMID:17087503]

Authors

Sukumar N, Chen ZW, Ferrari D, Merli A, Rossi GL, Bellamy HD, Chistoserdov A, Davidson VL, Mathews FS

Title

Crystal structure of an electron transfer complex between aromatic amine dehydrogenase and azurin from Alcaligenes faecalis.

Journal

Biochemistry 45:13500-10 (2006)
DOI:10.1021/bi0612972

Sequence

[ag:CAL23525 CAL23524]

Other DBs

ExplorEnz - The Enzyme Database:

IUBMB Enzyme Nomenclature:

ExPASy - ENZYME nomenclature database:

BRENDA, the Enzyme Database:

LinkDB

DBGET integrated database retrieval system