| Entry |
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| Name |
[amino-group carrier protein]-gamma-(L-lysyl)-L-glutamate aminotransferase;
lysJ (gene name)
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| Class |
Transferases;
Transferring nitrogenous groups;
Transaminases
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| Sysname |
2-oxoglutarate:[amino-group carrier protein]-C-terminal-[gamma-(L-lysyl)-L-glutamate] aminotransferase
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| Reaction(IUBMB) |
an [amino-group carrier protein]-C-terminal-[gamma-(L-lysyl)-L-glutamate] + 2-oxoglutarate = an [amino-group carrier protein]-C-terminal-[N-(1-carboxy-5-oxopentyl)-L-glutamine] + L-glutamate [RN: R09778]
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| Reaction(KEGG) |
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| Substrate |
[amino-group carrier protein]-C-terminal-[gamma-(L-lysyl)-L-glutamate];
2-oxoglutarate [CPD: C00026]
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| Product |
[amino-group carrier protein]-C-terminal-[N-(1-carboxy-5-oxopentyl)-L-glutamine];
L-glutamate [CPD: C00025]
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| Comment |
The enzyme participates in an L-lysine biosynthesis pathway in certain species of archaea and bacteria.
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| History |
EC 2.6.1.118 created 2019
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| Pathway |
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| Orthology |
| K05830 | [amino-group carrier protein]-gamma-(L-lysyl/L-ornithyl)-L-glutamate aminotransferase |
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| Genes |
| DTAE: | LAJ19_05695 LAJ19_17015 |
| CABY: | Cabys_1935 Cabys_3152(argD) |
| HPEL: | HZS54_04340 HZS54_10875 |
| STO: | STK_01910(argD_lysJ) |
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| Reference |
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| Authors |
Miyazaki J, Kobashi N, Nishiyama M, Yamane H |
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| Title |
Functional and evolutionary relationship between arginine biosynthesis and prokaryotic lysine biosynthesis through alpha-aminoadipate. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Horie A, Tomita T, Saiki A, Kono H, Taka H, Mineki R, Fujimura T, Nishiyama C, Kuzuyama T, Nishiyama M |
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| Title |
Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.6.1.118 |
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| LinkDB |
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