 | | DRUG: Donepezil hydrochloride | |
| Entry |
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| Name |
Donepezil hydrochloride (JP18/USP);
Aricept (TN) |
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| Product |
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| Generic |
DONEPEZIL (A-S Medication Solutions), DONEPEZIL (American Health Packaging), DONEPEZIL (Camber Pharmaceuticals), DONEPEZIL (Quallent Pharmaceuticals Health LLC), DONEPEZIL HYDROCHLORIDE (A-S Medication Solutions), DONEPEZIL HYDROCHLORIDE (A-S Medication Solutions), DONEPEZIL HYDROCHLORIDE (ACI Healthcare USA), DONEPEZIL HYDROCHLORIDE (Alembic Pharmaceuticals Limited), DONEPEZIL HYDROCHLORIDE (Alembic Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (Aurobindo Pharma Limited), DONEPEZIL HYDROCHLORIDE (Bryant Ranch Prepack), DONEPEZIL HYDROCHLORIDE (Bryant Ranch Prepack), DONEPEZIL HYDROCHLORIDE (Bryant Ranch Prepack), DONEPEZIL HYDROCHLORIDE (Bryant Ranch Prepack), DONEPEZIL HYDROCHLORIDE (Bryant Ranch Prepack), DONEPEZIL HYDROCHLORIDE (Bryant Ranch Prepack), DONEPEZIL HYDROCHLORIDE (Bryant Ranch Prepack), DONEPEZIL HYDROCHLORIDE (Bryant Ranch Prepack), DONEPEZIL HYDROCHLORIDE (Bryant Ranch Prepack), DONEPEZIL HYDROCHLORIDE (Bryant Ranch Prepack), DONEPEZIL HYDROCHLORIDE (Bryant Ranch Prepack), DONEPEZIL HYDROCHLORIDE (Bryant Ranch Prepack), DONEPEZIL HYDROCHLORIDE (Bryant Ranch Prepack), DONEPEZIL HYDROCHLORIDE (Bryant Ranch Prepack), DONEPEZIL HYDROCHLORIDE (Cadila Pharmaceuticals Limited), DONEPEZIL HYDROCHLORIDE (Cardinal Health 107), DONEPEZIL HYDROCHLORIDE (DirectRx), DONEPEZIL HYDROCHLORIDE (Direct_Rx), DONEPEZIL HYDROCHLORIDE (Direct_Rx), DONEPEZIL HYDROCHLORIDE (Direct_Rx), DONEPEZIL HYDROCHLORIDE (Dr. Reddys Laboratories Limited), DONEPEZIL HYDROCHLORIDE (Dr. Reddys Laboratories Limited), DONEPEZIL HYDROCHLORIDE (Edenbridge Pharmaceuticals LLC.), DONEPEZIL HYDROCHLORIDE (Golden State Medical Supply), DONEPEZIL HYDROCHLORIDE (Golden State Medical Supply), DONEPEZIL HYDROCHLORIDE (Graviti Pharmaceuticals Private Limited), DONEPEZIL HYDROCHLORIDE (Lupin Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (Macleods Pharmaceuticals Limited), DONEPEZIL HYDROCHLORIDE (Major Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (NCS HealthCare of KY), DONEPEZIL HYDROCHLORIDE (NCS HealthCare of KY), DONEPEZIL HYDROCHLORIDE (NuCare Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (Preferred Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (Preferred Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (Proficient Rx LP), DONEPEZIL HYDROCHLORIDE (Proficient Rx LP), DONEPEZIL HYDROCHLORIDE (RedPharm Drug), DONEPEZIL HYDROCHLORIDE (Rising Pharma Holdings), DONEPEZIL HYDROCHLORIDE (ScieGen Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (Solco Healthcare US), DONEPEZIL HYDROCHLORIDE (Solco Healthcare US), DONEPEZIL HYDROCHLORIDE (Strides Pharma Science Limited), DONEPEZIL HYDROCHLORIDE (Sun Pharmaceutical Industries), DONEPEZIL HYDROCHLORIDE (TWi Pharmaceuticals), DONEPEZIL HYDROCHLORIDE (Torrent Pharmaceuticals Limited), DONEPEZIL HYDROCHLORIDE (Unichem Pharmaceuticals (USA)), DONEPEZIL HYDROCHLORIDE (Zydus Lifesciences Limited), DONEPEZIL HYDROCHLORIDE (Zydus Lifesciences Limited), DONEPEZIL HYDROCHLORIDE (Zydus Lifesciences Limited), DONEPEZIL HYDROCHLORIDE (Zydus Pharmaceuticals USA), DONEPEZIL HYDROCHLORIDE (Zydus Pharmaceuticals USA) |
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| Formula |
C24H29NO3. HCl
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| Exact mass |
415.1914
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| Mol weight |
415.95
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| Structure |
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| Simcomp |
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| Class |
Neuropsychiatric agent
DG01595 Cholinesterase inhibitor
DG01593 Acetylcholinesterase inhibitor
DG01968 Antidementia agent
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
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| Remark |
| Therapeutic category: | 1190 |
| Product (DG00983): | D07869<JP> D00670<JP/US> |
| Product (mixture): | D11387<US> |
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| Efficacy |
Dementia therapeutic agent, Acetylcholinesterase inhibitor |
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| Disease |
Dementia of the Alzheimer's type [DS: H00056] |
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]; CYP2D6 [HSA: 1565]
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| Interaction |
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| Structure map |
| map07056 | Agents for Alzheimer-type dementia |
| map07220 | Cholinergic and anticholinergic drugs |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06D ANTI-DEMENTIA DRUGS
N06DA Anticholinesterases
N06DA02 Donepezil
D00670 Donepezil hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Antidementia Agents
Cholinesterase Inhibitors
Donepezil
D00670 Donepezil hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
119 Miscellaneous
1190 Miscellaneous
D00670 Donepezil hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01595 Cholinesterase inhibitor
DG01593 Acetylcholinesterase inhibitor
DG00983 Donepezil
D00670 Donepezil hydrochloride
DG01968 Antidementia agent
DG00983 Donepezil
D00670 Donepezil hydrochloride
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00983 Donepezil
D00670 Donepezil hydrochloride
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00983 Donepezil
D00670 Donepezil hydrochloride
Drug classes [BR:br08332]
Neuropsychiatric agent
DG01968 Antidementia agent
D00670 Donepezil hydrochloride
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
Carboxylic-ester hydrolases
ACHE
D00670 Donepezil hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00670 Donepezil hydrochloride
D00670 Donepezil hydrochloride tablets
D00670 Donepezil hydrochloride fine granules
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00670
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01595 Cholinesterase inhibitor
DG01593 Acetylcholinesterase inhibitor
DG00983 Donepezil
DG01968 Antidementia agent
DG00983 Donepezil
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00983 Donepezil
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00983 Donepezil
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 29
1 X Cl 25.2087 -22.5699
2 C8y C 24.0800 -25.5500
3 C8x C 24.0800 -26.9500
4 C8x C 25.2924 -27.6500
5 C8x C 26.5049 -26.9500
6 C8x C 26.5049 -25.5500
7 C8x C 25.2924 -24.8500
8 C1b C 22.8676 -24.8500
9 N1y N 21.6721 -25.5404
10 C1x C 20.4847 -24.8549
11 C1x C 19.2723 -25.5550
12 C1y C 19.2724 -26.9550
13 C1x C 20.4597 -27.6404
14 C1x C 21.6721 -26.9404
15 C1b C 18.0455 -27.6636
16 C1y C 16.8381 -26.9666
17 C5x C 16.8881 -25.5501
18 C8y C 15.5615 -25.0643
19 C8y C 14.6895 -26.1759
20 C1x C 15.4772 -27.3487
21 O5x O 18.0372 -24.7769
22 C8x C 15.0396 -23.7652
23 C8y C 13.6536 -23.5677
24 C8y C 12.7816 -24.6793
25 C8x C 13.3035 -25.9784
26 O2a O 13.1387 -22.2867
27 C1a C 11.7702 -22.2314
28 O2a O 11.4279 -24.6970
29 C1a C 10.7132 -23.4957
BOND 31
1 2 3 2
2 3 4 1
3 4 5 2
4 5 6 1
5 6 7 2
6 2 7 1
7 2 8 1
8 8 9 1
9 9 10 1
10 10 11 1
11 11 12 1
12 12 13 1
13 13 14 1
14 9 14 1
15 12 15 1
16 15 16 1
17 16 17 1
18 17 18 1
19 18 19 1
20 19 20 1
21 16 20 1
22 17 21 2
23 18 22 2
24 22 23 1
25 23 24 2
26 24 25 1
27 19 25 2
28 23 26 1
29 26 27 1
30 24 28 1
31 28 29 1
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