 | | DRUG: Distigmine bromide | |
| Entry |
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| Name |
Distigmine bromide (JP18/INN);
Ubretid (TN) |
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| Formula |
C22H32N4O4. 2Br
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| Exact mass |
574.0790
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| Mol weight |
576.32
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| Structure |
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| Simcomp |
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| Class |
Neuropsychiatric agent
DG01595 Cholinesterase inhibitor
DG01593 Acetylcholinesterase inhibitor
DG01719 Parasympathomimetic agent
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
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| Remark |
| Product (DG00989): | D01228<JP> |
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| Efficacy |
Acetylcholinesterase inhibitor |
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| Comment |
Quaternary ammonium compound
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| Target |
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| Pathway |
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| Interaction |
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N07 OTHER NERVOUS SYSTEM DRUGS
N07A PARASYMPATHOMIMETICS
N07AA Anticholinesterases
N07AA03 Distigmine
D01228 Distigmine bromide (JP18/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
12 Agents affecting peripheral nervous system
123 Autonomic nervous system agents
1231 Quaternary ammoniums
D01228 Distigmine bromide (JP18/INN)
13 Agents affecting sensory organs
131 Ophthalmic agents
1312 Miotic agents
D01228 Distigmine bromide (JP18/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01595 Cholinesterase inhibitor
DG01593 Acetylcholinesterase inhibitor
DG00989 Distigmine
D01228 Distigmine bromide
DG01719 Parasympathomimetic agent
DG00989 Distigmine
D01228 Distigmine bromide
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
D01228 Distigmine bromide
Drug classes [BR:br08332]
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
D01228 Distigmine bromide
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
Carboxylic-ester hydrolases
ACHE
D01228 Distigmine bromide (JP18/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01228 Distigmine bromide
D01228 Distigmine bromide tablets
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01595 Cholinesterase inhibitor
DG01593 Acetylcholinesterase inhibitor
DG00989 Distigmine
DG01719 Parasympathomimetic agent
DG00989 Distigmine
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 32
1 X Br 10.8112 -13.6523 #-
2 X Br 32.7804 -20.1826 #-
3 C8y C 29.7353 -17.3380
4 C8x C 29.7284 -18.7366
5 N5y N 30.9361 -19.4420 #+
6 C8x C 32.1507 -18.7488
7 C8x C 32.1578 -17.3503
8 C8x C 30.9502 -16.6449
9 C8y C 14.0147 -16.7005
10 O7a O 15.2248 -17.3903
11 C8x C 14.0147 -15.2917
12 C8x C 12.7989 -17.3962
13 C7a C 16.4406 -16.6947
14 N5y N 12.7989 -14.5844 #+
15 C8x C 11.5772 -16.7005
16 N1c N 17.6566 -17.3845
17 O6a O 16.4348 -15.2800
18 C8x C 11.5772 -15.2917
19 C1a C 12.8047 -13.1816
20 C1b C 18.8667 -16.6771
21 C1a C 17.6566 -18.7875
22 C1b C 20.0796 -17.3662
23 C1b C 21.2803 -16.6669
24 C1b C 22.4953 -17.3592
25 C1b C 23.6960 -16.6599
26 C1b C 24.9110 -17.3521
27 N1c N 26.1117 -16.6529
28 C7a C 27.3267 -17.3450
29 O7a O 28.5275 -16.6458
30 O6a O 27.3196 -18.7436
31 C1a C 30.9686 -20.8345
32 C1a C 26.1051 -15.2323
BOND 31
1 9 11 1
2 9 12 2
3 10 13 1
4 11 14 2
5 12 15 1
6 13 16 1
7 13 17 2
8 14 18 1
9 14 19 1
10 16 20 1
11 16 21 1
12 15 18 2
13 4 5 2
14 20 22 1
15 5 6 1
16 22 23 1
17 6 7 2
18 23 24 1
19 7 8 1
20 24 25 1
21 8 3 2
22 25 26 1
23 26 27 1
24 27 28 1
25 28 29 1
26 29 3 1
27 3 4 1
28 28 30 2
29 9 10 1
30 5 31 1
31 27 32 1
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