 | | DRUG: Physostigmine sulfate | |
| Entry |
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| Name |
Physostigmine sulfate (USP);
Eserine sulfate (TN) |
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| Formula |
(C15H21N3O2)2. H2SO4
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| Exact mass |
648.2941
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| Mol weight |
648.77
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| Structure |
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| Class |
Neuropsychiatric agent
DG01595 Cholinesterase inhibitor
DG01593 Acetylcholinesterase inhibitor
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
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| Remark |
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| Efficacy |
Acetylcholinesterase inhibitor (ophthalmic) |
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| Comment |
Reversible cholinesterase inhibitor
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| Target |
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| Pathway |
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| Interaction |
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| Structure map |
| map07056 | Agents for Alzheimer-type dementia |
| map07220 | Cholinergic and anticholinergic drugs |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
S01EB Parasympathomimetics
S01EB05 Physostigmine
D03826 Physostigmine sulfate (USP)
V VARIOUS
V03 ALL OTHER THERAPEUTIC PRODUCTS
V03A ALL OTHER THERAPEUTIC PRODUCTS
V03AB Antidotes
V03AB19 Physostigmine
D03826 Physostigmine sulfate (USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01595 Cholinesterase inhibitor
DG01593 Acetylcholinesterase inhibitor
DG01132 Physostigmine
D03826 Physostigmine sulfate
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG01132 Physostigmine
D03826 Physostigmine sulfate
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
Carboxylic-ester hydrolases
ACHE
D03826 Physostigmine sulfate (USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01595 Cholinesterase inhibitor
DG01593 Acetylcholinesterase inhibitor
DG01132 Physostigmine
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG01132 Physostigmine
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 45
1 C1z C 33.2500 -17.1500
2 C8y C 31.9900 -17.5700
3 C1y C 34.0900 -18.2700
4 C1x C 34.0200 -16.0300
5 C1a C 32.4100 -16.0300
6 C8y C 31.9900 -18.9700
7 C8x C 30.7300 -16.8700
8 N1y N 33.2500 -19.3900
9 N1y N 35.4200 -17.8500
10 C1x C 35.4200 -16.4500
11 C8x C 30.7300 -19.6700
12 C8y C 29.5400 -17.5700
13 C1a C 33.8100 -20.7200
14 C8x C 29.5400 -18.9700
15 O7a O 28.3500 -16.8700
16 C7a C 27.0900 -17.5700
17 N1b N 25.9000 -16.8700
18 O6a O 27.0900 -18.9700
19 C1a C 24.7100 -17.5700
20 C1a C 36.4700 -18.6900
21 S4a S 43.2600 -18.2000
22 O1d O 44.6600 -18.2000
23 O1d O 41.8600 -18.2000
24 O1d O 43.2600 -16.8000
25 O1d O 43.2600 -19.6000
26 C1z C 33.2500 -17.1500
27 C8y C 31.9900 -17.5700
28 C8y C 31.9900 -18.9700
29 N1y N 33.2500 -19.3900
30 C1y C 34.0900 -18.2700
31 N1y N 35.4200 -17.8500
32 C1x C 35.4200 -16.4500
33 C1x C 34.0200 -16.0300
34 C1a C 36.4700 -18.6900
35 C1a C 33.8100 -20.7200
36 C8x C 30.7300 -19.6700
37 C8x C 29.5400 -18.9700
38 C8y C 29.5400 -17.5700
39 C8x C 30.7300 -16.8700
40 O7a O 28.3500 -16.8700
41 C7a C 27.0900 -17.5700
42 N1b N 25.9000 -16.8700
43 C1a C 24.7100 -17.5700
44 O6a O 27.0900 -18.9700
45 C1a C 32.4100 -16.0300
BOND 48
1 21 22 1
2 21 23 1
3 21 24 2
4 21 25 2
5 16 17 1
6 16 18 2
7 17 19 1
8 6 8 1
9 9 10 1
10 12 14 2
11 1 2 1
12 1 3 1
13 1 4 1
14 1 5 1 #Up
15 2 6 1
16 2 7 2
17 3 8 1
18 3 9 1
19 4 10 1
20 6 11 2
21 7 12 1
22 8 13 1
23 11 14 1
24 12 15 1
25 15 16 1
26 9 20 1
27 41 42 1
28 41 44 2
29 42 43 1
30 28 29 1
31 31 32 1
32 38 37 2
33 26 27 1
34 26 30 1
35 26 33 1
36 26 45 1 #Up
37 27 28 1
38 27 39 2
39 30 29 1
40 30 31 1
41 33 32 1
42 28 36 2
43 39 38 1
44 29 35 1
45 36 37 1
46 38 40 1
47 40 41 1
48 31 34 1
BRACKET 1 22.1900 -21.4900 22.1900 -14.4900
1 38.4300 -14.4900 38.4300 -21.4900
1 2
ORIGINAL 1 1 2 6 8 3 20 9 10 4 21 13 11 14 12 7 15
1 16 17 19 18 5
REPEAT 1 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42
1 43 44 45 46 47
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