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KEGG   DRUG: Amfetamine
Entry
D07445                      Drug                                   
Name
Amfetamine (INN);
Amphetamine;
Amfetamin (TN);
Adzenys (TN);
Dyanavel (TN)
Product
Formula
C9H13N
Exact mass
135.1048
Mol weight
135.21
Structure
Simcomp
Class
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Remark
Same as: C07514
ATC code: N06BA01
Chemical structure group: DG00966
Product (DG00966): D07445<US> D02074<US>
Efficacy
Stimulant (central)
  Disease
Attention deficit hyperactivity disorder [DS:H01895]
Target
SLC18A2 (VMAT2) [HSA:6571] [KO:K08155]
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
SLC6A3 (DAT1) [HSA:6531] [KO:K05036]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
hsa05031  Amphetamine addiction
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Structure map
map07234  Neurotransmitter transporter inhibitors
Other map
map05031  Amphetamine addiction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06B PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
    N06BA Centrally acting sympathomimetics
     N06BA01 Amfetamine
      D07445  Amfetamine (INN) <US>
USP drug classification [BR:br08302]
 Central Nervous System Agents
  Attention Deficit Hyperactivity Disorder Agents, Amphetamines
   Amphetamine
    D07445  Amfetamine (INN)
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00966  Amfetamine
    D07445  Amfetamine
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D07445  Amfetamine (INN) <US>
    SLC6A3 (DAT1)
     D07445  Amfetamine (INN) <US>
   SLC18
    SLC18A2 (VMAT2)
     D07445  Amfetamine (INN) <US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07445
Prodrugs [br08324.html]
 D07445
Narcotics and psychotropics in Japan [br08308.html]
 Stimulants by Control Act Article 2 Appended Table and Cabinet Order
  D07445
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00966  Amfetamine
Other DBs
CAS: 300-62-9
PubChem: 51091776
ChEBI: 2679
LigandBox: D07445
NIKKAJI: J231.296D
LinkDB
KCF data

ATOM        10
            1   C8y C    18.0426  -15.4812
            2   C8x C    16.8566  -14.7835
            3   C8x C    18.0426  -16.8766
            4   C1b C    19.2287  -14.7835
            5   C8x C    15.6008  -15.4812
            6   C8x C    16.8566  -17.5742
            7   C1c C    20.4845  -15.4812
            8   C8x C    15.6008  -16.8766
            9   N1a N    21.6705  -14.7835
            10  C1a C    20.4845  -16.8766
BOND        10
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     5   8 2
            8     7   9 1
            9     7  10 1
            10    6   8 1

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