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KEGG   DISEASE: Trichotillomania
Entry
H00864                      Disease                                
Name
Trichotillomania
Description
Trichotillomania (TTM) is a chronic behavioral disorder characterized by the irresistible urge to pull out one's hair, resulting in noticeable hair loss. Mutations in SLITRK1 are found in patients with TTM.
Category
Mental and behavioural disorder
Brite
Human diseases in ICD-11 classification [BR:br08403]
 06 Mental, behavioural or neurodevelopmental disorders
  Obsessive-compulsive or related disorders
   6B25  Body-focused repetitive behaviour disorders
    H00864  Trichotillomania
Gene
SLITRK1 [HSA:114798] [KO:K25832]
Comment
Mutations in SLITRK1 are also found in patients with Tourette syndrome. [DS:H00862]
Other DBs
ICD-11: 6B25.0
MeSH: D014256
OMIM: 613229
Reference
PMID:17003809
  Authors
Zuchner S, Cuccaro ML, Tran-Viet KN, Cope H, Krishnan RR, Pericak-Vance MA, Wright HH, Ashley-Koch A
  Title
SLITRK1 mutations in trichotillomania.
  Journal
Mol Psychiatry 11:887-9 (2006)
DOI:10.1038/sj.mp.4001865
Reference
PMID:18794888
  Authors
Katayama K, Yamada K, Ornthanalai VG, Inoue T, Ota M, Murphy NP, Aruga J
  Title
Slitrk1-deficient mice display elevated anxiety-like behavior and noradrenergic abnormalities.
  Journal
Mol Psychiatry 15:177-84 (2010)
DOI:10.1038/mp.2008.97
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