KEGG ORTHOLOGY: K08669

ORTHOLOGY: K08669

Entry

K08669                      KO

Symbol

HTRA2, PRSS25

Name

HtrA serine peptidase 2 [EC:3.4.21.108]

Pathway

map04210

Apoptosis

map04214

Apoptosis - fly

map04215

Apoptosis - multiple species

map05012

Parkinson disease

map05022

Pathways of neurodegeneration - multiple diseases

Disease

H00057

Parkinson disease

H00754

3-Methylglutaconic aciduria

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K08669  HTRA2, PRSS25; HtrA serine peptidase 2
   04214 Apoptosis - fly
    K08669  HTRA2, PRSS25; HtrA serine peptidase 2
   04215 Apoptosis - multiple species
    K08669  HTRA2, PRSS25; HtrA serine peptidase 2
09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K08669  HTRA2, PRSS25; HtrA serine peptidase 2
   05022 Pathways of neurodegeneration - multiple diseases
    K08669  HTRA2, PRSS25; HtrA serine peptidase 2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K08669  HTRA2, PRSS25; HtrA serine peptidase 2
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts
    K08669  HTRA2, PRSS25; HtrA serine peptidase 2
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.108  HtrA2 peptidase
     K08669  HTRA2, PRSS25; HtrA serine peptidase 2
Peptidases and inhibitors [BR:ko01002]
Serine peptidases
  Family S1: chymotrypsin family
   K08669  HTRA2, PRSS25; HtrA serine peptidase 2
Chaperones and folding catalysts [BR:ko03110]
Other chaperones and cochaperones
  DegP / HtrA
   K08669  HTRA2, PRSS25; HtrA serine peptidase 2

Genes

HSA:	27429(HTRA2)

PTR:	459339(HTRA2)

PPS:	100985283(HTRA2)

GGO:	101153780(HTRA2)

PON:	100461940(HTRA2)

PPYG:

129029966(HTRA2)

NLE:	100591213(HTRA2)

HMH:	116483898(HTRA2)

SSYN:

129461556(HTRA2)

MCC:	709938(HTRA2)

MCF:	102126403(HTRA2)

MTHB:

126933984

MNI:	105465308(HTRA2)

CSAB:

103220019(HTRA2)

CATY:

105596870(HTRA2)

PANU:

100999628(HTRA2)

TGE:	112637005(HTRA2)

MLEU:

105540209(HTRA2)

RRO:	104674825(HTRA2)

RBB:	108531686(HTRA2)

TFN:	117062068(HTRA2)

PTEH:

111523451(HTRA2)

CANG:

105514609(HTRA2)

CJC:	100385512(HTRA2)

SBQ:	101046884(HTRA2)

CIMI:

108289325(HTRA2)

ANAN:

105717145(HTRA2)

CSYR:

103251916(HTRA2)

MMUR:

105884574(HTRA2)

LCAT:

123637092(HTRA2)

PCOQ:

105821488(HTRA2)

OGA:	100965412(HTRA2)

MMU:	64704(Htra2)

MCAL:

110295867(Htra2)

MPAH:

110317283(Htra2)

RNO:	297376(Htra2)

MCOC:

116099123(Htra2)

ANU:	117715331(Htra2)

MUN:	110541049(Htra2)

CGE:	100760629(Htra2)

MAUA:

101833773(Htra2)

PROB:

127235774(Htra2)

PLEU:

114694427(Htra2)

MORG:

121439551(Htra2)

MFOT:

126515304

AAMP:

119806736(Htra2)

NGI:	103726986(Htra2)

HGL:	101725239(Htra2)

CPOC:

100734064(Htra2)

CCAN:

109692441(Htra2)

DORD:

105999574(Htra2)

DSP:	122125215(Htra2)

PLOP:

125356383(Htra2)

MMMA:

107154234(Htra2)

OCU:

100338967

OPI:	101517086(HTRA2)

TUP:	102501824(HTRA2)

GVR:	103593845(HTRA2)

CFA:	475782(HTRA2)

CLUD:

112664260(HTRA2)

VVP:	112916707(HTRA2)

VLG:	121490681(HTRA2)

NPO:	129501268(HTRA2)

AML:	100471770(HTRA2)

UMR:	103671421(HTRA2)

UAH:	113243611(HTRA2)

UAR:	123786085(HTRA2)

ELK:

111148182

LLV:

125108306

MPUF:

101681959(HTRA2)

MNP:	132021422(HTRA2)

MLK:	131840338(HTRA2)

NVS:	122915023(HTRA2)

ORO:	101375505 101382419(HTRA2)

EJU:	114218893(HTRA2)

ZCA:	113936941(HTRA2)

MLX:	118007942(HTRA2)

NSU:	110588722(HTRA2)

LWW:	102732477(HTRA2)

FCA:	768259(HTRA2)

PYU:	121019218(HTRA2)

PCOO:

112869042(HTRA2)

PBG:	122497060(HTRA2)

PVIV:

125161606(HTRA2)

LRUF:

124502982

PTG:	102968855(HTRA2)

PPAD:

109263345(HTRA2)

PUC:

125937141

AJU:

106988577

HHV:	120237033(HTRA2)

BTA:	523039(HTRA2)

BOM:

102273081

BIU:	109565903(HTRA2)

BBUB:

102389817(HTRA2)

BBIS:

104980877(HTRA2)

CHX:	102181963(HTRA2)

OAS:	101120228(HTRA2)

BTAX:

128055221(HTRA2)

ODA:	120851251(HTRA2)

CCAD:

122441473(HTRA2)

MBEZ:

129538979(HTRA2)

SSC:	100512831(HTRA2)

CFR:	102522927(HTRA2)

CBAI:

105078073(HTRA2)

CDK:	105105950(HTRA2)

VPC:	102534828(HTRA2)

BACU:

103003966(HTRA2)

BMUS:

118905936(HTRA2)

LVE:	103086746(HTRA2)

OOR:	101276862(HTRA2)

DLE:	111169079(HTRA2)

PCAD:

102995172(HTRA2)

PSIU:

116764730(HTRA2)

NASI:

112413631(HTRA2)

ECB:	100053688(HTRA2)

EPZ:	103557683(HTRA2)

EAI:	106823864(HTRA2)

MYB:	102242360(HTRA2)

MYD:	102772576(HTRA2)

MMYO:

118668824(HTRA2)

MLF:	102430969(HTRA2)

MDT:	132213178(HTRA2)

PKL:	118717574(HTRA2) 118726900

EFUS:

103291391(HTRA2)

MNA:	107529250(HTRA2)

DRO:	112303094(HTRA2)

SHON:

119000105(HTRA2)

AJM:	119038363(HTRA2)

PDIC:

114500921(HTRA2)

PHAS:

123811483(HTRA2)

MMF:	118630461(HTRA2)

PPAM:

129086785(HTRA2)

HAI:	109371208(HTRA2)

RFQ:	117033097(HTRA2)

PALE:

102890616(HTRA2)

PGIG:

120594570(HTRA2)

PVP:	105290726(HTRA2)

RAY:	107502930(HTRA2)

MJV:	108402276(HTRA2)

TOD:	119259102(HTRA2)

SARA:

101537740(HTRA2)

SETR:

126024593(HTRA2)

LAV:	100659066(HTRA2)

TMU:

101344176

ETF:	101644287(HTRA2)

DNM:	101422887(HTRA2)

MDO:	100025882(HTRA2)

GAS:	123251237(HTRA2)

SHR:	100923981(HTRA2)

AFZ:

127541189

PCW:	110221089(HTRA2)

TVP:	118853046(HTRA2)

OAA:	114811155(HTRA2)

GGA:	395990(HTRA2)

PCOC:

116225954(HTRA2)

MGP:	100538527(HTRA2)

CJO:	107306835(HTRA2)

TPAI:

128071993(HTRA2)

LMUT:

125692673(HTRA2)

NMEL:

110390926(HTRA2)

APLA:

101802615(HTRA2)

ACYG:

106043211(HTRA2)

CATA:

118260606(HTRA2)

AFUL:

116489251(HTRA2)

TGU:	115494796(HTRA2)

LSR:	110468691(HTRA2)

SCAN:

103823115(HTRA2)

PMOA:

120509181(HTRA2)

OTC:	121334999(HTRA2)

PRUF:

121364686(HTRA2)

GFR:	102042326(HTRA2)

FAB:	101806812(HTRA2)

OMA:	130252080(HTRA2)

PHI:	102107154(HTRA2)

PMAJ:

107203523(HTRA2)

CCAE:

111929153(HTRA2)

CCW:	104690945(HTRA2)

CBRC:

103621144(HTRA2)

ETL:	114068870(HTRA2)

ZAB:	102073494(HTRA2)

ZLE:	135447179(HTRA2)

SVG:	106853114(HTRA2)

MMEA:

130575443(HTRA2)

HRT:	120753458(HTRA2)

SATI:

136360317(HTRA2)

FPG:	101914636(HTRA2)

FCH:	102050387(HTRA2)

CCRI:

104158899(HTRA2)

NNT:	104407518(HTRA2)

SHAB:

115603591(HTRA2)

ACUN:

113490506(HTRA2)

TALA:

104357118(HTRA2)

ACHC:

115338040(HTRA2)

HALD:

104323727

HLE:	104832327(HTRA2)

AGEN:

126034425

GCL:

127015433

LDI:

104344932

DPUB:

104304160(HTRA2)

EGZ:	104130002(HTRA2)

NNI:	104013943(HTRA2)

PCRI:

104033270(HTRA2)

PCAO:

104048057

PADL:

103922175(HTRA2)

AFOR:

103902152(HTRA2)

FGA:

104077444

GSTE:

104253882(HTRA2)

CLV:	102085893(HTRA2)

PLET:

104627978(HTRA2)

CUCA:

104056875(HTRA2)

BREG:

104631783(HTRA2)

OHA:	104327021(HTRA2)

CPEA:

104398131(HTRA2)

CVF:	104294205(HTRA2)

RTD:	128910329(HTRA2)

AAM:	106487415(HTRA2)

AROW:

112978200(HTRA2)

NPD:	112954033(HTRA2)

TGT:

104575976

DNE:	112995277(HTRA2)

SCAM:

104141829(HTRA2)

ASN:	102378167(HTRA2)

AMJ:	102573820(HTRA2)

CPOO:

109324453(HTRA2)

GGN:

109291026

PSS:	102456624(HTRA2)

CMY:	102937290(HTRA2)

CCAY:

125635208(HTRA2)

DCC:	119854643(HTRA2)

CPIC:

101936375(HTRA2)

TST:	117878397(HTRA2)

CABI:

116830477(HTRA2)

MRV:	120406783(HTRA2)

ACS:	100565079(htra2)

ASAO:

132777143(HTRA2)

PVT:	110079828(HTRA2)

SUND:

121931747(HTRA2)

PBI:	103059726(HTRA2)

PMUR:

107292494(HTRA2)

CTIG:

120303956(HTRA2)

TSR:	106538932(HTRA2)

PGUT:

117670678(HTRA2)

APRI:

131203309(HTRA2)

PTEX:

113447164(HTRA2)

NSS:	113417909(HTRA2)

VKO:	123022581(HTRA2)

PMUA:

114603783(HTRA2)

PRAF:

128420645(HTRA2)

ZVI:	118095517(HTRA2)

HCG:	128326349(HTRA2)

GJA:	107110467(HTRA2)

STOW:

125439669(HTRA2)

EMC:	129336917(HTRA2)

XLA:	108706463(htra2.S)

XTR:	100492982(htra2)

NPR:

108804097

RTEM:

120921526(HTRA2)

BBUF:

120990589(HTRA2)

BGAR:

122923779(HTRA2)

MUO:	115461203(HTRA2)

GSH:	117365207(HTRA2)

DRE:	100137109(htra2-14) 100149563 110438948 110438965 560917 797799 799791(htra2-7)

SRX:	107708385 107733689

SANH:

SGH:

CAUA:

CGIB:

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

CERY:

MASI:

TROS:

TDW:

MANU:

IPU:

IFU:

PHYP:

113539574(htra2)

SMEO:

TFD:

TVC:

TRN:

AMEX:

CMAO:

EEE:	113585783(htra2)

CHAR:

105899646

TRU:	101079124(htra2)

TFS:

130540195

TNG:	GSTEN00032214G001

LCO:

104921575

NCC:

104960364

TBEN:

117480412

CGOB:

115027100(htra2)

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116669612(htra2)

PFLV:

114546640(htra2)

GAT:

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

CUD:

ALAT:

MZE:

ONL:

OAU:

OLA:

OML:

CSAI:

XMA:	102226566(htra2)

XCO:	114134420(htra2)

XHE:	116708980 116708981

PRET:

103458895(htra2)

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

AOCE:

111578923(htra2)

MCEP:

CSEM:

POV:

SSEN:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:

SLAL:

111651107(htra2)

XGL:

120795653

HCQ:	109522905(htra2)

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

110155255(htra2)

MALB:

BSPL:

SJO:

SASA:

STRU:

OTW:

OMY:

OGO:

OKI:

OKE:

SALP:

SNH:

CCLU:

ELS:

SFM:

PKI:

AANG:

LOC:	102688355(htra2)

PSPA:

121315538 121331242

ARUT:

117409633 117420941

PSEX:

120527899

LCM:	102356234(HTRA2)

CMK:

CPLA:

LERI:

BFO:

BBEL:

SCLV:

SPU:	115918650 756975

LPIC:

APLC:

ARUN:

AJC:

SKO:

DME:	Dmel_CG8464(HtrA2)

DER:

6552632

DSE:

6606394

DSI:	Dsimw501_GD20417(Dsim_GD20417)

DYA:	Dyak_GE26447

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI24802

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108364219 108379064

AOQ:

129235390

TDA:	119678863 119683986

MDE:	101893592 131801165

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:	119650663 119650665 119653370

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ005160 CpipJ_CPIJ019291

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105672452(HtrA2)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:	122509625 122509666

LBD:	127286547 127286589

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:	657089 657173

DPA:

109538837

SOY:	115883491 115885849

AGRG:

126739416 126739657

ATD:	109603615 109605817

CSET:

123321414 123322973

AGB:	108909361 108914966

LDC:	111516164 111516878

DVV:	114341488 126885264

NVL:	108558222 108561986

APLN:

108736222 108744581

PPYR:

116173013 116174078 116174361

OTU:	111415963 111417190

BMOR:

100533207(htra2)

BMAN:

MSEX:

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:	113495117 113495493

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CFEL:

CCRN:

BTAB:

DCI:

CLEC:

HHAL:

106679589(HtrA2)

NLU:

111049046

HVI:

124359809

MQU:

128986285

PHU:	Phum_PHUM529710

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

FCD:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:	135225265 135225266

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

DPTE:

CSCU:

CVS:	136987301(HtrA2)

PTEP:

UDV:

SDM:

LPOL:

PMEO:

TSP:	Tsp_09197 Tsp_09212

HRO:	HELRODRAFT_82139

PCAN:

112565039

BGT:	106059316 106067187

GAE:

121384327

HRF:

124117397

HRJ:	124267384 124281929

CRG:

CANU:

CVN:

OED:

MCAF:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_211260

SHX:	MS3_00005043(HTRA2_1)

OVI:	T265_06722

EGL:

LLON:

NVE:

EPA:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

HSY:

RES:	135692652 135695982

TAD:	TRIADDRAFT_58565

AQU:	100637088 105312877

ATH:	AT5G27660(DEG14)

ALY:	9308332 9325896

CRB:

17883659

CSAT:

104707036 104736749 104771198

EUS:	EUTSA_v10004245mg

BRP:

103874520

BNA:	106348679 106407376

BOE:

106306356

RSZ:	108854973 130495218

THJ:

104802800

CIT:

102608405

CIC:	CICLE_v10001167mg

PVY:

116111841

MINC:

123197839

TCC:	18600461 18600462

GRA:

GHI:

GAB:

HSYR:

DZI:

EGR:	104415569 104417702 104429273

GSJ:

114398353

PVU:	PHAVU_006G090500g

VRA:

VAR:

MTR:

TPRA:

CAM:

PSAT:

VVO:

LJA:	130731173 130731177

ADU:

107492133

AIP:

107645908

AHF:	112695532 112758373

LANG:

109329681

QSA:	O6P43_007498

PPER:

18772880

PMUM:

103344586

PAVI:

110759195

MDM:	103408538 103430468

PXB:

103965318

ZJU:

107411888

MNT:	21383913 21390093

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

MEAN:

JCU:

HBR:

MESC:

POP:

PEU:

PALZ:

PNZ:

JRE:

CILL:

CAVE:

QSU:

QLO:	115979360 115979955 115980370

TWL:	120010734 120011045

VVI:

VRI:

CANN:

LBB:

NTA:	107774648 107790499

NSY:

NTO:

NAU:

INI:

ITR:

SIND:

OEU:

EGT:	105960795 105966285

SSPL:

SMIL:

SHIS:

APAN:

HAN:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

AEW:

BVG:

SOE:

CQI:

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:

OBR:

OGL:

BDI:

ATS:

TDC:	119286577 119295187

TAES:

123086771 123091208 123096196

TUA:

125550711

LPER:

127293991 127293993

LRD:	124699588 124699771 124699772

SBI:

ZMA:

MFLO:

SITA:

SVS:

PVIR:

PHAI:

PDA:

EGU:

MUS:	103989835 103996468 103997483

ZOF:	122001036 122005320 122017557 122049217

DCT:

PEQ:

AOF:

MSIN:

ATR:

SMO:	SELMODRAFT_164697 SELMODRAFT_185147

PPP:

112283886

CSL:	COCSUDRAFT_28277

CVR:	CHLNCDRAFT_18457

APRO:

F751_2338

CCP:	CHC_T00007659001

PIF:	PITG_03582

PSOJ:

PHYSODRAFT_537128

SPAR:

SPRG_10340

IDO:	I598_0941(htrA_1)

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Reference

PMID:19502560

Authors

Balakrishnan MP, Cilenti L, Mashak Z, Popat P, Alnemri ES, Zervos AS

Title

THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death.

Journal

Am J Physiol Heart Circ Physiol 297:H643-53 (2009)
DOI:10.1152/ajpheart.00234.2009

Sequence

[hsa:27429]

Reference

PMID:10971580

Authors

Gray CW, Ward RV, Karran E, Turconi S, Rowles A, Viglienghi D, Southan C, Barton A, Fantom KG, West A, Savopoulos J, Hassan NJ, Clinkenbeard H, Hanning C, Amegadzie B, Davis JB, Dingwall C, Livi GP, Creasy CL

Title

Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response.

Journal

Eur J Biochem 267:5699-710 (2000)
DOI:10.1046/j.1432-1327.2000.01589.x

Sequence

[hsa:27429]

LinkDB

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