KEGG ORTHOLOGY: K19448

ORTHOLOGY: K19448

Entry

K19448                      KO

Symbol

UL39

Name

Simplexvirus ribonucleoside-diphosphate reductase large subunit [EC:1.17.4.1]

Pathway

map05168

Herpes simplex virus 1 infection

Network

nt06168 Herpes simplex virus 1 (HSV-1)
nt06524 Apoptosis

Element

N00579

HSV ICP6 to extrinsic apoptotic pathway

Brite

KEGG Orthology (KO) [BR:ko00001]
09160 Human Diseases
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    K19448  UL39; Simplexvirus ribonucleoside-diphosphate reductase large subunit
09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K19448  UL39; Simplexvirus ribonucleoside-diphosphate reductase large subunit
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.17  Acting on CH or CH2 groups
   1.17.4  With a disulfide as acceptor
    1.17.4.1  ribonucleoside-diphosphate reductase
     K19448  UL39; Simplexvirus ribonucleoside-diphosphate reductase large subunit
Viral proteins [BR:ko03200]
dsDNA viruses
  Human herpes simplex virus 1/2
   K19448  UL39; Simplexvirus ribonucleoside-diphosphate reductase large subunit

Other DBs

GO:

0004748

Genes

VG:	1487325(UL39) 1487434(UL39) 18533931(UL39) 19621683(UL39) 26828076(UL39) 26887604(AZ249_gp43) 2703361(UL39) 3190322(UL39) 32707792(UL39) 3850222(UL39) 9829317(UL39)

Reference

PMID:18990579

Authors

Lembo D, Brune W

Title

Tinkering with a viral ribonucleotide reductase.

Journal

Trends Biochem Sci 34:25-32 (2009)
DOI:10.1016/j.tibs.2008.09.008

Sequence

[vg:1487325]

Reference

PMID:29321311

Authors

Mostafa HH, Thompson TW, Konen AJ, Haenchen SD, Hilliard JG, Macdonald SJ, Morrison LA, Davido DJ

Title

Herpes Simplex Virus 1 Mutant with Point Mutations in UL39 Is Impaired for Acute Viral Replication in Mice, Establishment of Latency, and Explant-Induced Reactivation.

Journal

J Virol 92:e01654-17 (2018)
DOI:10.1128/JVI.01654-17

Sequence

[vg:2703361]

LinkDB

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