 | | NETWORK: N00442 | |
| Entry |
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| Name |
HIV Nef to TNF-NFKB signaling pathway
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| Definition |
Nef -> (RIPK1+TRADD+TRAF2/5) -> (TAB1/2/3+TAK1) -> IKK -> NFKBIA -> NFKB |
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| Expanded |
K22891 -> (8737+8717+(7186,7188)) -> ((10454,23118,257397)+6885) -> (1147+3551+8517) -> 4792 -> (4790+5970) |
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| Class |
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| Type |
Pathogen
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| Pathway |
| hsa05170 | Human immunodeficiency virus 1 infection |
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| Disease |
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| Gene |
| 8737 | RIPK1; receptor interacting serine/threonine kinase 1 |
| 8717 | TRADD; TNFRSF1A associated via death domain |
| 7186 | TRAF2; TNF receptor associated factor 2 |
| 7188 | TRAF5; TNF receptor associated factor 5 |
| 10454 | TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 |
| 23118 | TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2 |
| 257397 | TAB3; TGF-beta activated kinase 1 (MAP3K7) binding protein 3 |
| 6885 | MAP3K7; mitogen-activated protein kinase kinase kinase 7 |
| 1147 | CHUK; conserved helix-loop-helix ubiquitous kinase |
| 3551 | IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta |
| 8517 | IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma |
| 4792 | NFKBIA; NFKB inhibitor alpha |
| 4790 | NFKB1; nuclear factor kappa B subunit 1 |
| 5970 | RELA; RELA proto-oncogene, NF-kB subunit |
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| Perturbant |
| K22891 (Nef) | nef; HIV-1 protein Nef |
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| Reference |
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| Authors |
Pasquereau S, Kumar A, Herbein G |
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| Title |
Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: from Immune Activation to Viral Reservoirs. |
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| Journal |
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| Reference |
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| Authors |
Khan KA, Abbas W, Varin A, Kumar A, Di Martino V, Dichamp I, Herbein G |
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| Title |
HIV-1 Nef interacts with HCV Core, recruits TRAF2, TRAF5 and TRAF6, and stimulates HIV-1 replication in macrophages. |
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| Journal |
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| LinkDB |
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