 | | NETWORK: N00980 | |
| Entry |
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| Name |
Mutation-caused aberrant Htt to REST-mediated transcriptional repression
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| Definition |
HTT* // REST == (SIN3A+RCOR1+(HDAC1,HDAC2)) =| BDNF |
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| Expanded |
3064v1 // 5978 == (25942+23186+(3065,3066)) =| 627 |
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| Class |
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| Type |
Variant
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| Pathway |
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| Disease |
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| Gene |
| 5978 | REST; RE1 silencing transcription factor |
| 25942 | SIN3A; SIN3 transcription regulator family member A |
| 23186 | RCOR1; REST corepressor 1 |
| 3065 | HDAC1; histone deacetylase 1 |
| 3066 | HDAC2; histone deacetylase 2 |
| 627 | BDNF; brain derived neurotrophic factor |
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| Variant |
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| Reference |
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| Authors |
Landles C, Bates GP |
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| Title |
Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series. |
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| Journal |
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| Reference |
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| Authors |
Cattaneo E, Zuccato C, Tartari M |
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| Title |
Normal huntingtin function: an alternative approach to Huntington's disease. |
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| Journal |
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| Reference |
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| Authors |
Moumne L, Betuing S, Caboche J |
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| Title |
Multiple Aspects of Gene Dysregulation in Huntington's Disease. |
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| Journal |
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| LinkDB |
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DBGET integrated database retrieval system