KEGG NETWORK: N00983

NETWORK: N00983

Entry

N00983                      Network

Name

Mutation-caused aberrant Htt to extrinsic apoptotic pathway

Definition

HTT* // (HIP1+IFT57) -> CASP8 -> CASP3

Expanded

3064v1 // (3092+55081) -> 841 -> 836

Class

nt06461 Huntington disease

Type

Variant

Pathway

hsa05016

Huntington disease

Disease

H00059

Huntington disease

Gene

3064	HTT; huntingtin

3092	HIP1; huntingtin interacting protein 1

55081

IFT57; intraflagellar transport 57

841	CASP8; caspase 8

836	CASP3; caspase 3

Variant

3064v1 (HTT*) HTT mutation

Reference

PMID:11807533

Authors

Mattson MP.

Title

Accomplices to neuronal death.

Journal

Nature 415:377-9 (2002)
DOI:10.1038/415377a

Reference

PMID:11788820

Authors

Gervais FG, Singaraja R, Xanthoudakis S, Gutekunst CA, Leavitt BR, Metzler M, Hackam AS, Tam J, Vaillancourt JP, Houtzager V, Rasper DM, Roy S, Hayden MR, Nicholson DW.

Title

Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.

Journal

Nat Cell Biol 4:95-105 (2002)
DOI:10.1038/ncb735

LinkDB

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