KEGG NETWORK: N01022

NETWORK: N01022

Entry

N01022                      Network

Name

Mutation-inactivated PRKN to Parkin-mediated ubiquitination

Definition

UBCH7/8 // PRKN* // PAELR

Expanded

(7332,9246) // 5071v1 // 2861

Class

nt06463 Parkinson disease
nt06466 Pathways of neurodegeneration

Type

Variant

Pathway

hsa05012

Parkinson disease

Disease

H00057

Parkinson disease

Gene

7332	UBE2L3; ubiquitin conjugating enzyme E2 L3

9246	UBE2L6; ubiquitin conjugating enzyme E2 L6

5071	PRKN; parkin RBR E3 ubiquitin protein ligase

2861	GPR37; G protein-coupled receptor 37

Variant

5071v1 (PRKN*) PRKN mutation

Reference

PMID:10973942

Authors

Imai Y, Soda M, Takahashi R

Title

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity.

Journal

J Biol Chem 275:35661-4 (2000)
DOI:10.1074/jbc.C000447200

Reference

PMID:12814656

Authors

Dev KK, van der Putten H, Sommer B, Rovelli G

Title

Part I: parkin-associated proteins and Parkinson's disease.

Journal

Neuropharmacology 45:1-13 (2003)
DOI:10.1016/s0028-3908(02)00337-4

Reference

PMID:23710284

Authors

Omura T, Kaneko M, Okuma Y, Matsubara K, Nomura Y

Title

Endoplasmic reticulum stress and Parkinson's disease: the role of HRD1 in averting apoptosis in neurodegenerative disease.

Journal

Oxid Med Cell Longev 2013:239854 (2013)
DOI:10.1155/2013/239854

LinkDB

DBGET integrated database retrieval system