KEGG NETWORK: N01026

NETWORK: N01026

Entry

N01026                      Network

Name

Mutation-inactivated PRKN to Parkin-mediated ubiquitination

Definition

UBCH7/8 // PRKN* // SYPH1

Expanded

(7332,9246) // 5071v1 // 9627

Class

nt06463 Parkinson disease
nt06466 Pathways of neurodegeneration

Type

Variant

Pathway

Parkinson disease

Disease

Parkinson disease

Gene

7332	UBE2L3; ubiquitin conjugating enzyme E2 L3

9246	UBE2L6; ubiquitin conjugating enzyme E2 L6

5071	PRKN; parkin RBR E3 ubiquitin protein ligase

9627	SNCAIP; synuclein alpha interacting protein

Variant

5071v1 (PRKN*) PRKN mutation

Reference

Authors

Chung KK, Zhang Y, Lim KL, Tanaka Y, Huang H, Gao J, Ross CA, Dawson VL, Dawson TM.

Title

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease.

Journal

Nat Med 7:1144-50 (2001)
DOI:10.1038/nm1001-1144

Reference

Authors

Dev KK, van der Putten H, Sommer B, Rovelli G

Title

Part I: parkin-associated proteins and Parkinson's disease.

Journal

Neuropharmacology 45:1-13 (2003)
DOI:10.1016/s0028-3908(02)00337-4

LinkDB

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