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KEGG   NETWORK: N01032
Entry
N01032                      Network                                
Name
Mutation-inactivated PRKN to mGluR1 signaling pathway
Definition
PRKN* -> PLCG1 -> IP3 -> ITPR -> Ca2+
  Expanded
5071v1 -> 5335 -> C01245 -> (3708,3709,3710) -> C00076
Class
nt06463 Parkinson disease
nt06466 Pathways of neurodegeneration
Type
Variant
Pathway
hsa05012  Parkinson disease
Disease
H00057  Parkinson disease
Gene
5071  PRKN; parkin RBR E3 ubiquitin protein ligase
5335  PLCG1; phospholipase C gamma 1
3708  ITPR1; inositol 1,4,5-trisphosphate receptor type 1
3709  ITPR2; inositol 1,4,5-trisphosphate receptor type 2
3710  ITPR3; inositol 1,4,5-trisphosphate receptor type 3
Variant
5071v1 (PRKN*)  PRKN mutation
Metabolite
C01245  D-myo-Inositol 1,4,5-trisphosphate
C00076  Calcium cation
Reference
PMID:24781149
  Authors
Cali T, Ottolini D, Brini M
  Title
Calcium signaling in Parkinson's disease.
  Journal
Cell Tissue Res 357:439-54 (2014)
DOI:10.1007/s00441-014-1866-0
Reference
PMID:19663908
  Authors
Sandebring A, Dehvari N, Perez-Manso M, Thomas KJ, Karpilovski E, Cookson MR, Cowburn RF, Cedazo-Minguez A
  Title
Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling.
  Journal
FEBS J 276:5041-52 (2009)
DOI:10.1111/j.1742-4658.2009.07201.x
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