KEGG NETWORK: N01035

NETWORK: N01035

Entry

N01035                      Network

Name

Mutation-caused aberrant SNCA to PERK-ATF4 signaling pathway

Definition

SNCA* -| BIP -| EIF2AK3 -> EIF2S1 -> ATF4 => DDIT3

Expanded

6622v1 -| 3309 -| 9451 -> 1965 -> 468 => 1649

Class

nt06534 Unfolded protein response
nt06463 Parkinson disease
nt06466 Pathways of neurodegeneration

Type

Variant

Pathway

hsa05012

Parkinson disease

Disease

H00057

Parkinson disease

Gene

6622	SNCA; synuclein alpha

3309	HSPA5; heat shock protein family A (Hsp70) member 5

9451	EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3

1965	EIF2S1; eukaryotic translation initiation factor 2 subunit alpha

468	ATF4; activating transcription factor 4

1649	DDIT3; DNA damage inducible transcript 3

Variant

6622v1 (SNCA*) SNCA mutation

Reference

PMID:23352769

Authors

Mercado G, Valdes P, Hetz C

Title

An ERcentric view of Parkinson's disease.

Journal

Trends Mol Med 19:165-75 (2013)
DOI:10.1016/j.molmed.2012.12.005

Reference

PMID:27103567

Authors

Mercado G, Castillo V, Soto P, Sidhu A

Title

ER stress and Parkinson's disease: Pathological inputs that converge into the secretory pathway.

Journal

Brain Res 1648:626-632 (2016)
DOI:10.1016/j.brainres.2016.04.042

Reference

PMID:26297973

Authors

Tsujii S, Ishisaka M, Hara H

Title

Modulation of endoplasmic reticulum stress in Parkinson's disease.

Journal

Eur J Pharmacol 765:154-6 (2015)
DOI:10.1016/j.ejphar.2015.08.033

Reference

PMID:31100053

Authors

Shah A, Chao J, Legido-Quigley C, Chang RC

Title

Oxyresveratrol exerts ATF4- and Grp78-mediated neuroprotection against endoplasmic reticulum stress in experimental Parkinson's disease.

Journal

Nutr Neurosci 1-16 (2019)
DOI:10.1080/1028415X.2019.1613764

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