| Entry |
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| Name |
Mutation-inactivated VAPB to ATF6-mediated transcription
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| Definition |
VAPB* -| ATF6 |
|---|
| Expanded |
9217v1 -| 22926 |
|---|
| Class |
nt06534 Unfolded protein response
nt06464 Amyotrophic lateral sclerosis
nt06466 Pathways of neurodegeneration
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| Type |
Variant
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| Pathway |
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| Disease |
| H00058 | Amyotrophic lateral sclerosis (ALS) |
|
|---|
| Gene |
| 9217 | VAPB; VAMP associated protein B and C |
| 22926 | ATF6; activating transcription factor 6 |
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| Variant |
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| Reference |
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| Authors |
Gkogkas C, Middleton S, Kremer AM, Wardrope C, Hannah M, Gillingwater TH, Skehel P |
|---|
| Title |
VAPB interacts with and modulates the activity of ATF6. |
|---|
| Journal |
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| Reference |
|
|---|
| Authors |
Kanekura K, Nishimoto I, Aiso S, Matsuoka M |
|---|
| Title |
Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8). |
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| Journal |
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| Reference |
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| Authors |
Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A |
|---|
| Title |
Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders. |
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| Journal |
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|---|
| Reference |
|
|---|
| Authors |
Webster CP, Smith EF, Shaw PJ, De Vos KJ |
|---|
| Title |
Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities? |
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| Journal |
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| LinkDB |
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