KEGG NETWORK: N01399

NETWORK: N01399

Entry

N01399                      Network

Name

Benzene to CYP-mediated metabolism

Definition

BZ -- (CYP2E1,CYP2F1) -> C01782 -> Phenol -- CYP2E1 -> HQ -> Cu -> Superoxide

Expanded

C01407 -- (1571,1572) -> C01782 -> C00146 -- 1571 -> C00530 -> C00070 -> C00704

Class

nt06251 CYP-mediated ROS formation (cancer)

Type

Env factor

Pathway

hsa05208

Chemical carcinogenesis - reactive oxygen species

Disease

H00003

Acute myeloid leukemia

Gene

1571	CYP2E1; cytochrome P450 family 2 subfamily E member 1

1572	CYP2F1; cytochrome P450 family 2 subfamily F member 1

Perturbant

C01407 (BZ)

Benzene

Metabolite

C01782

Benzene oxide

C00146

Phenol

C00530

Hydroquinone

C00070

Copper

C00704

Superoxide

Reference

PMID:22166497

Authors

McHale CM, Zhang L, Smith MT

Title

Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment.

Journal

Carcinogenesis 33:240-52 (2012)
DOI:10.1093/carcin/bgr297

Reference

PMID:32977499

Authors

Scharf P, Broering MF, Oliveira da Rocha GH, Farsky SHP

Title

Cellular and Molecular Mechanisms of Environmental Pollutants on Hematopoiesis.

Journal

Int J Mol Sci 21:E6996 (2020)
DOI:10.3390/ijms21196996

Reference

PMID:9118888

Authors

Snyder R, Hedli CC

Title

An overview of benzene metabolism.

Journal

Environ Health Perspect 104 Suppl 6:1165-71 (1996)
DOI:10.1289/ehp.961041165

Reference

PMID:11978484

Authors

Kawanishi S, Hiraku Y, Murata M, Oikawa S

Title

The role of metals in site-specific DNA damage with reference to carcinogenesis.

Journal

Free Radic Biol Med 32:822-32 (2002)
DOI:10.1016/S0891-5849(02)00779-7

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