KEGG NETWORK: N01530

NETWORK: N01530

Entry

N01530                      Network

Name

Dopamine metabolism

Definition

Tyr+BH4 -- TH -> L-Dopa -- DDC -> Dopamine -- MAO -> DOPAL

Expanded

(C00082+C00272) -- 7054 -> C00355 -- 1644 -> C03758 -- (4128,4129) -> C04043

Class

nt06028 Dopamine and serotonin metabolism
nt06463 Parkinson disease

Type

Reference

Pathway

hsa00350

Tyrosine metabolism

hsa04728

Dopaminergic synapse

Gene

7054	TH; tyrosine hydroxylase

1644	DDC; dopa decarboxylase

4128	MAOA; monoamine oxidase A

4129	MAOB; monoamine oxidase B

Metabolite

C00082

L-Tyrosine

C00272

Tetrahydrobiopterin

C00355

3,4-Dihydroxy-L-phenylalanine

C03758

Dopamine

C04043

3,4-Dihydroxyphenylacetaldehyde

Reference

PMID:24548101

Authors

Segura-Aguilar J, Paris I, Munoz P, Ferrari E, Zecca L, Zucca FA

Title

Protective and toxic roles of dopamine in Parkinson's disease.

Journal

J Neurochem 129:898-915 (2014)
DOI:10.1111/jnc.12686

Reference

PMID:24409201

Authors

Jones DR, Moussaud S, McLean P

Title

Targeting heat shock proteins to modulate alpha-synuclein toxicity.

Journal

Ther Adv Neurol Disord 7:33-51 (2014)
DOI:10.1177/1756285613493469

Reference

PMID:31351996

Authors

Burbulla LF, Krainc D

Title

The role of dopamine in the pathogenesis of GBA1-linked Parkinson's disease.

Journal

Neurobiol Dis 132:104545 (2019)
DOI:10.1016/j.nbd.2019.104545

Reference

PMID:28761417

Authors

Segura-Aguilar J

Title

On the role of endogenous neurotoxins and neuroprotection in Parkinson's disease.

Journal

Neural Regen Res 12:897-901 (2017)
DOI:10.4103/1673-5374.208560

LinkDB

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