KEGG NETWORK: N01644

NETWORK: N01644

Entry

N01644                      Network

Name

Lysosomal Ca2+ release

Definition

PI(3.5)P2 -> MCOLN1 -> Ca2+(cyto) -> CALM == CN -> TFEB

Expanded

C11556 -> 57192 -> C00076 -> (801,805,808) == ((5530,5532,5533)+(5534,5535)) -> 7942

Class

nt06528 Calcium signaling

Type

Reference

Pathway

hsa04020

Calcium signaling pathway

Gene

57192

MCOLN1; mucolipin TRP cation channel 1

801	CALM1; calmodulin 1

805	CALM2; calmodulin 2

808	CALM3; calmodulin 3

5530	PPP3CA; protein phosphatase 3 catalytic subunit alpha

5532	PPP3CB; protein phosphatase 3 catalytic subunit beta

5533	PPP3CC; protein phosphatase 3 catalytic subunit gamma

5534	PPP3R1; protein phosphatase 3 regulatory subunit B, alpha

5535	PPP3R2; protein phosphatase 3 regulatory subunit B, beta

7942	TFEB; transcription factor EB

Metabolite

C11556

1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate

C00076

Calcium cation

Reference

PMID:28725634

Authors

Kania E, Roest G, Vervliet T, Parys JB, Bultynck G

Title

IP(3) Receptor-Mediated Calcium Signaling and Its Role in Autophagy in Cancer.

Journal

Front Oncol 7:140 (2017)
DOI:10.3389/fonc.2017.00140

Reference

PMID:31795242

Authors

Ureshino RP, Erustes AG, Bassani TB, Wachilewski P, Guarache GC, Nascimento AC, Costa AJ, Smaili SS, Pereira GJDS

Title

The Interplay between Ca(2+) Signaling Pathways and Neurodegeneration.

Journal

Int J Mol Sci 20:E6004 (2019)
DOI:10.3390/ijms20236004

LinkDB

DBGET integrated database retrieval system