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KEGG   REACTION: R05858
Entry
R05858                      Reaction                               
Definition
Vindoline + Catharanthine <=> 3',4'-Anhydrovinblastine
Equation
Comment
unclear reaction
peroxidase
Reaction class
RC01481  C09107_C11641
RC01590  C01626_C11641
Pathway
rn00901  Indole alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00965  Vinblastine biosynthesis, geissoschizine => vinblastine
Orthology
K27796  peroxidase PRX1
Reference
1  [PMID:9654153]
  Authors
Sottomayor M, Lopez-Serrano M, DiCosmo F, Ros Barcelo A.
  Title
Purification and characterization of alpha-3',4'-anhydrovinblastine synthase (peroxidase-like) from Catharanthus roseus (L.) G. Don.
  Journal
FEBS Lett 428:299-303 (1998)
DOI:10.1016/S0014-5793(98)00551-1
Reference
2  [PMID:36045295]
  Authors
Zhang J, Hansen LG, Gudich O, Viehrig K, Lassen LMM, Schrubbers L, Adhikari KB, Rubaszka P, Carrasquer-Alvarez E, Chen L, D'Ambrosio V, Lehka B, Haidar AK, Nallapareddy S, Giannakou K, Laloux M, Arsovska D, Jorgensen MAK, Chan LJG, Kristensen M, Christensen HB, Sudarsan S, Stander EA, Baidoo E, Petzold CJ, Wulff T, O'Connor SE, Courdavault V, Jensen MK, Keasling JD.
  Title
A microbial supply chain for production of the anti-cancer drug vinblastine.
  Journal
Nature 609:341-347 (2022)
DOI:10.1038/s41586-022-05157-3
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