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KEGG   REACTION: R08294
Entry
R08294                      Reaction                               
Definition
Lidocaine + NADPH + Oxygen + H+ <=> 3-Hydroxylidocaine + NADP+ + H2O
Equation
Comment
CYP1A2, CYP3A4
Reaction class
RC00001  C00005_C00006
RC00046  C07073_C16560
Enzyme
1.14.14.1       1.14.14.-
Pathway
rn00982  Drug metabolism - cytochrome P450
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1
     R08294  Lidocaine + NADPH + Oxygen + H+ <=> 3-Hydroxylidocaine + NADP+ + H2O
    1.14.14.-
     R08294  Lidocaine + NADPH + Oxygen + H+ <=> 3-Hydroxylidocaine + NADP+ + H2O
Orthology
K07409  cytochrome P450 family 1 subfamily A2 [EC:1.14.14.1]
K17689  cytochrome P450 family 3 subfamily A4 [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
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