KEGG REACTION: R08380

REACTION: R08380

Entry

R08380                      Reaction

Name

11-cis-retinol: NADP+ oxidoreductase

Definition

11-cis-Retinol + NADP+ <=> 11-cis-Retinal + NADPH + H+

Equation

C00899 + C00006 <=> C02110 + C00005 + C00080

Reaction class

RC00001

C00005_C00006

RC00649

C00899_C02110

Enzyme

1.1.1.-

Pathway

rn00830

Retinol metabolism

Brite

Enzymatic reactions [BR:br08201]
1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-
     R08380  11-cis-Retinol + NADP+ <=> 11-cis-Retinal + NADPH + H+

Orthology

K11151

retinol dehydrogenase 10 [EC:1.1.1.-]

K11152

retinol dehydrogenase 11 [EC:1.1.1.300]

Reference

1 [PMID:19458327]

Authors

Farjo KM, Moiseyev G, Takahashi Y, Crouch RK, Ma JX

Title

The 11-cis-retinol dehydrogenase activity of RDH10 and its interaction with visual cycle proteins.

Journal

Invest Ophthalmol Vis Sci 50:5089-97 (2009)
DOI:10.1167/iovs.09-3797

Other DBs

RHEA:

54915

LinkDB

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