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Homo sapiens (human): 4538
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Entry
4538 CDS
T01001
Symbol
ND4, MTND4, MT-ND4, LHON
Name
(RefSeq) NADH dehydrogenase subunit 4
KO
K03881
NADH-ubiquinone oxidoreductase chain 4 [EC:
7.1.1.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00190
Oxidative phosphorylation
hsa01100
Metabolic pathways
hsa04714
Thermogenesis
hsa04723
Retrograde endocannabinoid signaling
hsa05010
Alzheimer disease
hsa05012
Parkinson disease
hsa05014
Amyotrophic lateral sclerosis
hsa05016
Huntington disease
hsa05020
Prion disease
hsa05022
Pathways of neurodegeneration - multiple diseases
hsa05208
Chemical carcinogenesis - reactive oxygen species
hsa05415
Diabetic cardiomyopathy
Module
hsa_M00142
NADH:ubiquinone oxidoreductase, mitochondria
Network
nt06460
Alzheimer disease
nt06463
Parkinson disease
nt06464
Amyotrophic lateral sclerosis
nt06466
Pathways of neurodegeneration
Element
N00995
Electron transfer in Complex I
N00997
Mutation-caused aberrant Abeta to electron transfer in Complex I
N01042
Mutation-caused aberrant SNCA to electron transfer in Complex I
N01043
Mutation-inactivated PINK1 to electron transfer in Complex I
N01044
MPP+ to electron transfer in Complex I
N01045
Rotenone to electron transfer in Complex I
N01136
Mutation-caused aberrant TDP43 to electron transfer in Complex I
Disease
H00068
Leber hereditary optic atrophy
H00473
Mitochondrial complex I deficiency
H01355
Kearns-Sayre syndrome
H01365
Leber hereditary optic neuropathy and dystonia
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09102 Energy metabolism
00190 Oxidative phosphorylation
4538 (ND4)
09150 Organismal Systems
09156 Nervous system
04723 Retrograde endocannabinoid signaling
4538 (ND4)
09159 Environmental adaptation
04714 Thermogenesis
4538 (ND4)
09160 Human Diseases
09161 Cancer: overview
05208 Chemical carcinogenesis - reactive oxygen species
4538 (ND4)
09164 Neurodegenerative disease
05010 Alzheimer disease
4538 (ND4)
05012 Parkinson disease
4538 (ND4)
05014 Amyotrophic lateral sclerosis
4538 (ND4)
05016 Huntington disease
4538 (ND4)
05020 Prion disease
4538 (ND4)
05022 Pathways of neurodegeneration - multiple diseases
4538 (ND4)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
4538 (ND4)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03029 Mitochondrial biogenesis [BR:
hsa03029
]
4538 (ND4)
Enzymes [BR:
hsa01000
]
7. Translocases
7.1 Catalysing the translocation of protons
7.1.1 Linked to oxidoreductase reactions
7.1.1.2 NADH:ubiquinone reductase (H+-translocating)
4538 (ND4)
Mitochondrial biogenesis [BR:
hsa03029
]
Mitochondrial DNA transcription, translation, and replication factors
Mitochondrial DNA-encoded proteins
Mitochondrial respiratory chain complex I
4538 (ND4)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Proton_antipo_M
Oxidored_q5_N
Motif
Other DBs
NCBI-GeneID:
4538
NCBI-ProteinID:
YP_003024035
OMIM:
516003
HGNC:
7459
UniProt:
P03905
H9EC08
Structure
PDB
LinkDB
All DBs
Position
MT:10760..12137
Genome browser
AA seq
459 aa
AA seq
DB search
MLKLIVPTIMLLPLTWLSKKHMIWINTTTHSLIISIIPLLFFNQINNNLFSCSPTFSSDP
LTTPLLMLTTWLLPLTIMASQRHLSSEPLSRKKLYLSMLISLQISLIMTFTATELIMFYI
FFETTLIPTLAIITRWGNQPERLNAGTYFLFYTLVGSLPLLIALIYTHNTLGSLNILLLT
LTAQELSNSWANNLMWLAYTMAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAAVLLKLGG
YGMMRLTLILNPLTKHMAYPFLVLSLWGMIMTSSICLRQTDLKSLIAYSSISHMALVVTA
ILIQTPWSFTGAVILMIAHGLTSSLLFCLANSNYERTHSRIMILSQGLQTLLPLMAFWWL
LASLANLALPPTINLLGELSVLVTTFSWSNITLLLTGLNMLVTALYSLYMFTTTQWGSLT
HHINNMKPSFTRENTLMFMHLSPILLLSLNPDIITGFSS
NT seq
1378 nt
NT seq
+upstream
nt +downstream
nt
atgctaaaactaatcgtcccaacaattatattactaccactgacatgactttccaaaaaa
cacataatttgaatcaacacaaccacccacagcctaattattagcatcatccctctacta
ttttttaaccaaatcaacaacaacctatttagctgttccccaaccttttcctccgacccc
ctaacaacccccctcctaatactaactacctgactcctacccctcacaatcatggcaagc
caacgccacttatccagtgaaccactatcacgaaaaaaactctacctctctatactaatc
tccctacaaatctccttaattataacattcacagccacagaactaatcatattttatatc
ttcttcgaaaccacacttatccccaccttggctatcatcacccgatgaggcaaccagcca
gaacgcctgaacgcaggcacatacttcctattctacaccctagtaggctcccttccccta
ctcatcgcactaatttacactcacaacaccctaggctcactaaacattctactactcact
ctcactgcccaagaactatcaaactcctgagccaacaacttaatatgactagcttacaca
atagcttttatagtaaagatacctctttacggactccacttatgactccctaaagcccat
gtcgaagcccccatcgctgggtcaatagtacttgccgcagtactcttaaaactaggcggc
tatggtataatacgcctcacactcattctcaaccccctgacaaaacacatagcctacccc
ttccttgtactatccctatgaggcataattataacaagctccatctgcctacgacaaaca
gacctaaaatcgctcattgcatactcttcaatcagccacatagccctcgtagtaacagcc
attctcatccaaaccccctgaagcttcaccggcgcagtcattctcataatcgcccacggg
cttacatcctcattactattctgcctagcaaactcaaactacgaacgcactcacagtcgc
atcataatcctctctcaaggacttcaaactctactcccactaatagctttttgatgactt
ctagcaagcctcgctaacctcgccttaccccccactattaacctactgggagaactctct
gtgctagtaaccacgttctcctgatcaaatatcactctcctacttacaggactcaacata
ctagtcacagccctatactccctctacatatttaccacaacacaatggggctcactcacc
caccacattaacaacataaaaccctcattcacacgagaaaacaccctcatgttcatacac
ctatcccccattctcctcctatccctcaaccccgacatcattaccgggttttcctctt
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