KEGG T01001: 5831

Homo sapiens (human): 5831

Entry

5831              CDS       T01001

Symbol

PYCR1, ARCL2B, ARCL3B, P5C, P5CR, PIG45, PP222, PRO3, PYCR

Name

(RefSeq) pyrroline-5-carboxylate reductase 1

K00286

pyrroline-5-carboxylate reductase [EC:1.5.1.2]

Organism

hsa Homo sapiens (human)

Pathway

hsa00330

Arginine and proline metabolism

hsa01100

Metabolic pathways

hsa01230

Biosynthesis of amino acids

Module

hsa_M00015

Proline biosynthesis, glutamate => proline

hsa_M00972

Proline metabolism

Network

nt06033 Glycine, serine and arginine metabolism

Element

N01618

Proline biosynthesis, Orn to Pro

Disease

H00557

Cutis laxa

H00558

Geroderma osteodysplasticum

Brite

KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    5831 (PYCR1)
Enzymes [BR:hsa01000]
1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.2  pyrroline-5-carboxylate reductase
     5831 (PYCR1)

SSDB

Motif

Pfam:

P5CR_dimer F420_oxidored NAD_Gly3P_dh_N Rossmann-like

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Pharos:

P32322(Tbio)

UniProt:

P32322

Structure

LinkDB

Position

17:complement(81932391..81937300)

AA seq 319 aa
MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETV
QHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIRC
MTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAY
AFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIH
ALHVLESGGFRSLLINAVEASCIRTRELQSMADQEQVSPAAIKKTILDKVKLDSPAGTAL
SPSGHTKLLPRSLAPAGKD

NT seq 960 nt +upstreamnt +downstreamnt
atgagcgtgggcttcatcggcgctggccagctggcttttgccctggccaagggcttcaca
gcagcaggcgtcttggctgcccacaagataatggctagctccccagacatggacctggcc
acagtttctgctctcaggaagatgggggtgaagttgacaccccacaacaaggagacggtg
cagcacagtgatgtgctcttcctggctgtgaagccacacatcatccccttcatcctggat
gaaataggcgccgacattgaggacagacacattgtggtgtcctgcgcggccggcgtcacc
atcagctccattgagaagaagctgtcagcgtttcggccagcccccagggtcatccgctgc
atgaccaacactccagtcgtggtgcgggagggggccaccgtgtatgccacaggcacgcac
gcccaggtggaggacgggaggctcatggagcagctgctgagcagcgtgggcttctgcacg
gaggtggaagaggacctgattgatgccgtcacggggctcagtggcagcggccccgcctac
gcattcacagccctggatgccctggctgatgggggtgtgaagatgggacttccaaggcgc
ctggcagtccgcctcggggcccaggccctcctgggggctgccaagatgctgctgcactca
gaacagcacccaggccagctcaaggacaacgtcagctctcctggtggggccaccatccat
gccttgcatgtgctggagagtgggggcttccgctccctgctcatcaacgctgtggaggcc
tcctgcatccgcacacgggagctgcagtccatggctgaccaggagcaggtgtcaccagcc
gccatcaagaagaccatcctggacaaggtgaagctggactcccctgcagggaccgctctg
tcaccttctggccacaccaagctgctcccccgcagcctggccccagcgggcaaggattga

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